Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNYKOT)

Drug Name
Zatebradine Drug Info
Synonyms UL-FS-49; UL-FS-49CL
Cross-matching ID
PubChem CID
65637
ChEBI ID
CHEMBL69679
CAS Number
CAS 85175-67-3
TTD Drug ID
D0NR3V

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Other types of O-glycan biosynthesis 1.87 4.84e-2 29/47 (61.7%) GALNT14;ST6GAL1;RFNG;...
Epithelial cell signaling in Helicobacter pylori infect... 1.87 2.42e-2 62/70 (88.57%) SRC;PAK1;ATP6V1D;...
Tyrosine metabolism -1.69 5.00e-2 30/36 (83.33%) ADH6;HGD;ADH1A;...
Pantothenate and CoA biosynthesis -1.75 2.78e-2 14/21 (66.67%) DPYS;DPYD;ENPP1
Staphylococcus aureus infection -1.78 2.83e-2 72/95 (75.79%) C5AR1;MBL2;C3AR1;...
Bladder cancer -1.81 2.29e-2 40/41 (97.56%) DAPK1;MMP9;CDKN1A;...
ABC transporters -1.82 3.06e-2 37/45 (82.22%) ABCG5;ABCC6;ABCC9;...
Complement and coagulation cascades -1.90 1.25e-2 76/85 (89.41%) CFHR4;A2M;MASP2;...
Steroid hormone biosynthesis -1.95 8.33e-3 43/61 (70.49%) CYP3A7;HSD17B7;SULT2B1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H