Details of the Drug Pharmacogenomic Perturbation Atlas

Radicicol Drug Info

AC1L1JGN; CHEMBL3972342; CTK6B6269

Cross-matching ID

PubChem CID

6323491

ChEBI ID

CHEMBL414883

CAS Number

CAS 12772-57-5

TTD Drug ID

D0ZA6G

General Information of Drug (ID: DMNZS94)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Protein processing in endoplasmic reticulum	3.01	0.00e+0	127/171 (74.27%)	HSPA1A;HSPA6;DNAJB1;...
Antigen processing and presentation	2.54	0.00e+0	60/78 (76.92%)	HSPA1A;HSPA6;HSPA8;...
Ferroptosis	2.31	2.39e-3	36/41 (87.8%)	HMOX1;SLC7A11;FTH1;...
Legionellosis	2.06	1.79e-3	51/57 (89.47%)	HSPA1A;HSPA6;HSPA8;...
Proteasome	2.02	2.87e-3	44/46 (95.65%)	PSMD14;PSMD1;PSMB7;...
Prion disease	1.93	8.38e-3	209/273 (76.56%)	HSPA1A;HSPA6;HSPA8;...
Estrogen signaling pathway	1.91	1.03e-2	119/137 (86.86%)	HSPA1A;HSPA6;HSPA8;...
Spliceosome	1.88	1.17e-2	101/150 (67.33%)	HSPA1A;HSPA6;HSPA8;...
Longevity regulating pathway	1.87	1.28e-2	90/151 (59.6%)	HSPA1A;HSPA6;HSPA8;...
Protein export	1.86	1.51e-2	17/23 (73.91%)	HSPA5;SRPRB;SEC63;...
Lipid and atherosclerosis	1.80	2.22e-2	190/215 (88.37%)	HSPA1A;HSPA6;HSPA8;...
TNF signaling pathway	-1.66	4.70e-2	103/112 (91.96%)	MAP3K5;JUN;FADD;...
TGF-beta signaling pathway	-1.66	4.58e-2	81/94 (86.17%)	BMPR1A;SMAD3;MAPK3;...
Maturity onset diabetes of the young	-1.68	3.75e-2	21/26 (80.77%)	PKLR;MNX1;HNF1B;...
Small cell lung cancer	-1.72	3.20e-2	90/92 (97.83%)	CDKN1A;IKBKB;LAMB3;...
NF-kappa B signaling pathway	-1.76	1.98e-2	90/104 (86.54%)	IL1R1;BCL10;IKBKB;...
Homologous recombination	-1.80	1.54e-2	35/41 (85.37%)	TOPBP1;SSBP1;MUS81;...
Cytosolic DNA-sensing pathway	-1.81	1.71e-2	52/63 (82.54%)	IKBKB;CCL5;POLR2E;...
AGE-RAGE signaling pathway in diabetic complications	-1.87	8.01e-3	97/100 (97%)	JUN;SMAD3;MAPK3;...
Cell cycle	-1.97	0.00e+0	110/124 (88.71%)	CDKN1A;PKMYT1;SMAD3;...
Nucleotide excision repair	-1.97	0.00e+0	40/47 (85.11%)	POLD1;GTF2H4;RFC3;...
Malaria	-1.98	0.00e+0	44/50 (88%)	ICAM1;GYPC;SDC1;...
Base excision repair	-2.06	0.00e+0	29/33 (87.88%)	MPG;MUTYH;POLB;...
Mismatch repair	-2.12	0.00e+0	22/23 (95.65%)	SSBP1;RFC5;MSH2;...
Fanconi anemia pathway	-2.22	0.00e+0	36/54 (66.67%)	BRIP1;FANCI;FAN1;...
DNA replication	-2.48	0.00e+0	34/36 (94.44%)	POLD1;POLA2;RFC3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	0.12uM - 20uM	6H, 24H, 48H

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
MCF7	CVCL_0031	Homo sapiens	0.04uM - 10uM	3H, 6H, 24H, 48H

MDA-MB-231	CVCL_0062	Homo sapiens	0.04uM - 10uM	3H, 24H

SK-BR-3	CVCL_0033	Homo sapiens	0.04uM - 10uM	3H, 24H

Breast carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
BT-20	CVCL_0178	Homo sapiens	0.04uM - 10uM	3H, 24H

Hs 578T	CVCL_0332	Homo sapiens	0.04uM - 10uM	3H, 24H

Normal (Epithelial)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HME1	CVCL_2950	Homo sapiens	0.04uM - 10uM	3H, 24H

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.04uM - 10uM	3H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.04uM - 10uM	6H, 24H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.04uM - 10uM	6H, 24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
1HAEo-	CVCL_0128	Homo sapiens	0.04uM - 10uM	24H

NL20	CVCL_0461	Homo sapiens	0.04uM - 10uM	24H

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	0.04uM - 10uM	6H, 24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.04uM - 10uM	6H, 24H, 48H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	0.04uM - 10uM	6H, 24H

Normal (Fibroblast)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
HFL1	CVCL_4295	Homo sapiens	0.04uM - 10uM	24H

IMR-90	CVCL_0347	Homo sapiens	0.04uM - 10uM	24H

WI-38	CVCL_0579	Homo sapiens	0.04uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
LNCaP	CVCL_0395	Homo sapiens	0.04uM - 10uM	3H, 24H

PC-3	CVCL_0035	Homo sapiens	0.04uM - 10uM	6H, 24H

VCaP	CVCL_2235	Homo sapiens	1.11uM - 20uM	6H, 24H, 48H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.04uM - 10uM	6H, 24H

Unclear

Rat sarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
XC	CVCL_1891	Rattus norvegicus (Rat)	10uM	24H