Details of the Drug Pharmacogenomic Perturbation Atlas

Acamprosate Drug Info

AOTA; Acamprosato; Acamprosatum; Acamprostate; Aotal; Campral; Calcium acetyl homotaurinate; Calcium acetylhomotaurinate; Calcium acetylhomotaurine; Sodium acetylhomotaurine; Acamprosate 6473; Acamprosate (Campral); Acamprosate (INN); Acamprosate [INN:BAN]; Acamprosato [INN-Spanish]; Acamprosatum [INN-Latin]; Aotal (TN); Campral (TN); N-Acetylhomotaurine; 3-(Acetylamino)propanesulphonic acid; 3-Acetamido-1-propanesulfonic acid; 3-acetamidopropane-1-sulfonic acid

Therapeutic Class

Alcohol Deterrents

Cross-matching ID

PubChem CID

71158

ChEBI ID

CHEMBL51041

CAS Number

CAS 77337-76-9

TTD Drug ID

D0GC2M

ACDINA Drug ID

D00006

General Information of Drug (ID: DMO381I)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.09	0.00e+0	34/36 (94.44%)	MCM3;PCNA;POLE2;...
Aminoacyl-tRNA biosynthesis	2.03	0.00e+0	15/66 (22.73%)	GATC;QRSL1;DARS2;...
Ribosome biogenesis in eukaryotes	1.94	0.00e+0	52/108 (48.15%)	RPP38;GNL3L;NAT10;...
T cell receptor signaling pathway	-1.62	4.76e-2	93/104 (89.42%)	MAPK13;NRAS;NFKBIE;...
ECM-receptor interaction	-1.63	4.65e-2	80/88 (90.91%)	COL4A1;COL2A1;ITGB3;...
MAPK signaling pathway	-1.63	4.47e-2	272/294 (92.52%)	RPS6KA3;CACNB3;MAPK13;...
Steroid biosynthesis	-1.64	4.39e-2	19/20 (95%)	HSD17B7;EBP;MSMO1;...
Endometrial cancer	-1.64	4.36e-2	56/58 (96.55%)	AXIN1;SOS2;MAPK1;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.65	4.49e-2	62/70 (88.57%)	CSK;GIT1;PTPN11;...
Renal cell carcinoma	-1.66	4.22e-2	68/69 (98.55%)	SOS2;MAPK1;EGLN1;...
PD-L1 expression and PD-1 checkpoint pathway in cancer	-1.66	4.05e-2	79/89 (88.76%)	MAPK13;NRAS;NFKBIE;...
Tight junction	-1.67	3.92e-2	130/169 (76.92%)	DLG3;DLG1;CD1C;...
Focal adhesion	-1.68	3.85e-2	180/201 (89.55%)	SOS2;BIRC3;LAMA3;...
Regulation of actin cytoskeleton	-1.68	3.99e-2	185/218 (84.86%)	SOS2;PIP4K2A;MAPK1;...
Regulation of lipolysis in adipocytes	-1.68	4.15e-2	52/55 (94.55%)	NPY;PTGER3;CGA;...
Fc gamma R-mediated phagocytosis	-1.70	3.68e-2	79/97 (81.44%)	MAPK3;ARPC1A;PRKCD;...
Synthesis and degradation of ketone bodies	-1.71	3.57e-2	9/10 (90%)	OXCT1;BDH2;ACAT1;...
mTOR signaling pathway	-1.71	3.83e-2	114/154 (74.03%)	LRP5;STK11;TELO2;...
Pentose phosphate pathway	-1.73	3.32e-2	25/30 (83.33%)	ALDOB;RPIA;RPE;...
Glycerolipid metabolism	-1.74	3.16e-2	44/61 (72.13%)	AKR1A1;ALDH2;PNPLA2;...
Type II diabetes mellitus	-1.76	2.97e-2	42/46 (91.3%)	MAPK3;SOCS1;PRKCD;...
GABAergic synapse	-1.77	2.48e-2	76/89 (85.39%)	GNAI2;GABBR2;GNG11;...
HIF-1 signaling pathway	-1.81	2.18e-2	105/109 (96.33%)	LTBR;RPS6;ALDOB;...
Vibrio cholerae infection	-1.82	1.96e-2	44/50 (88%)	PLCG2;ADCY3;ATP6V1E1;...
Synaptic vesicle cycle	-1.82	1.87e-2	63/78 (80.77%)	SLC1A2;SLC6A13;SLC6A12;...
Lysosome	-1.83	2.18e-2	115/128 (89.84%)	GUSB;PSAP;SLC11A2;...
B cell receptor signaling pathway	-1.86	1.31e-2	71/81 (87.65%)	LILRB4;SOS2;MAPK1;...
ErbB signaling pathway	-1.88	1.63e-2	79/85 (92.94%)	MAPK8;STAT5A;SOS2;...
Phagosome	-1.92	8.71e-3	118/152 (77.63%)	ITGA2;CD209;HLA-DOB;...
Yersinia infection	-1.95	6.54e-3	120/137 (87.59%)	ARHGEF7;MAPK3;ARPC1A;...
Collecting duct acid secretion	-1.96	1.31e-2	22/27 (81.48%)	ATP6V1E1;ATP6V0D1;ATP6V1C1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H