Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMO4XUC)

Drug Name
Diphenyl(piperidin-4-yl)methanol Drug Info
Synonyms
Azacyclonol; 115-46-8; diphenyl(piperidin-4-yl)methanol; alpha,alpha-diphenyl-4-piperidinomethanol; Frenquel; alpha,alpha-Diphenyl-4-piperidinemethanol; alpha-(4-Piperidyl)benzhydrol; gamma-Pipradol; Calmeran; Ataractan; Diphenyl-piperidin-4-yl-methanol; Diphenyl(4-piperidinyl)methanol; 4-Piperidinemethanol, alpha,alpha-diphenyl-; Azaciclonolo [DCIT]; Azacyklonol; Psychosan; MER 17; Frenoton; Azacyclonol [INN:BAN]; UNII-2MMR990PEM; Azacyclonolum [INN-Latin]; EINECS 204-092-5; Diphenyl-4-piperidylmethanol; BRN 0230221; 2MMR990PEM
Cross-matching ID
PubChem CID
15723
ChEBI ID
CHEMBL127508
CAS Number
CAS 115-46-8
TTD Drug ID
D08TBU
VARIDT Drug ID
DR00768

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis -1.88 1.47e-2 19/20 (95%) CYP2R1;EBP;DHCR7;...
Valine, leucine and isoleucine degradation -1.92 9.33e-3 42/48 (87.5%) ABAT;AACS;ACAA2;...
Arginine and proline metabolism -1.96 5.60e-3 39/50 (78%) MAOA;CNDP2;AMD1;...
Histidine metabolism -2.02 2.33e-3 16/22 (72.73%) MAOA;HAL;CNDP2;...
Fatty acid elongation -2.03 3.11e-3 19/27 (70.37%) ELOVL1;HACD2;PPT1;...
Terpenoid backbone biosynthesis -2.05 4.66e-3 18/22 (81.82%) HMGCS2;FNTB;IDI1;...
Biosynthesis of unsaturated fatty acids -2.08 0.00e+0 21/27 (77.78%) HACD2;HACD3;HACD1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H