General Information of Drug (ID: DMO794W)

Drug Name
Methenamine Drug Info
Synonyms Hiprex; Methenamine Hippurate
Cross-matching ID
PubChem CID
4101
ChEBI ID
CHEMBL6824
CAS Number
CAS 100-97-0
TTD Drug ID
D02LJR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Systemic lupus erythematosus 2.23 0.00e+0 45/135 (33.33%) HLA-DPB1;HLA-DPA1;HLA-DQA1;...
Graft-versus-host disease 2.22 0.00e+0 32/42 (76.19%) HLA-DPB1;HLA-DPA1;HLA-DQA1;...
Rheumatoid arthritis 2.14 0.00e+0 78/93 (83.87%) CXCL12;HLA-DPB1;HLA-DPA1;...
Autoimmune thyroid disease 2.09 0.00e+0 46/53 (86.79%) HLA-DPB1;HLA-DPA1;HLA-DQA1;...
Antigen processing and presentation 2.07 2.33e-3 60/78 (76.92%) HLA-DPB1;HLA-DPA1;HLA-DQA1;...
Allograft rejection 2.06 1.94e-3 32/38 (84.21%) HLA-DPB1;HLA-DPA1;HLA-DQA1;...
Primary immunodeficiency 1.99 1.66e-3 33/38 (86.84%) LCK;IL2RG;BLNK;...
Th17 cell differentiation 1.97 2.91e-3 95/107 (88.79%) MAPK13;HLA-DPB1;HLA-DPA1;...
Type I diabetes mellitus 1.92 2.59e-3 38/43 (88.37%) HLA-DPB1;HLA-DPA1;HLA-DQA1;...
Cell cycle 1.85 1.05e-2 110/124 (88.71%) PLK1;CCNB1;CCNB2;...
Inflammatory bowel disease 1.85 9.52e-3 58/65 (89.23%) MAF;HLA-DPB1;HLA-DPA1;...
Intestinal immune network for IgA production 1.84 9.70e-3 38/48 (79.17%) CXCL12;HLA-DPB1;HLA-DPA1;...
Th1 and Th2 cell differentiation 1.84 8.95e-3 80/92 (86.96%) MAF;MAPK13;HLA-DPB1;...
Propanoate metabolism 1.79 1.25e-2 30/34 (88.24%) ACAT2;DLD;ABAT;...
Spliceosome 1.78 1.32e-2 101/150 (67.33%) HSPA8;HSPA2;LSM3;...
Human T-cell leukemia virus 1 infection 1.77 1.60e-2 197/219 (89.95%) HLA-DPB1;CCNB2;HLA-DPA1;...
Oocyte meiosis 1.76 1.78e-2 90/129 (69.77%) PLK1;CCNB1;MAPK13;...
Glyoxylate and dicarboxylate metabolism 1.76 1.75e-2 23/30 (76.67%) ACAT2;DLD;ACO1;...
Asthma 1.76 1.65e-2 25/31 (80.65%) HLA-DPB1;HLA-DPA1;HLA-DQA1;...
Glycolysis / Gluconeogenesis 1.73 1.92e-2 56/67 (83.58%) PGAM1;ADH5;DLD;...
Viral protein interaction with cytokine and cytokine re... 1.72 1.83e-2 84/100 (84%) CXCL12;CXCL5;CXCL1;...
AMPK signaling pathway 1.70 2.22e-2 106/120 (88.33%) IRS2;CAB39;IGF1;...
T cell receptor signaling pathway 1.68 2.73e-2 93/104 (89.42%) MAPK13;LCK;MAP2K1;...
Measles 1.67 2.72e-2 133/139 (95.68%) HSPA8;HSPA2;HSPA6;...
DNA replication 1.66 2.84e-2 34/36 (94.44%) PCNA;PRIM1;POLA2;...
Valine, leucine and isoleucine degradation 1.64 3.45e-2 42/48 (87.5%) ACAT2;DLD;ALDH7A1;...
Progesterone-mediated oocyte maturation 1.61 4.35e-2 75/100 (75%) PLK1;CCNB1;MAPK13;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 12uM - 100uM 48H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.08uM - 100uM 3H, 24H, 48H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.08uM - 20uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H