Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMO90RN)

Drug Name
Y-27152 Drug Info
Synonyms
Y-27152; 127408-30-4; N-(Benzyloxy)-N-((3S,4R)-6-cyano-3-hydroxy-2,2-dimethylchroman-4-yl)acetamide; N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide; NCGC00092304-01; AC1OCF4F; SCHEMBL8864736; CHEMBL1476996; CHEBI:92752; CTK4B5603; MolPort-003-983-713; HMS3268J07; ZINC3789145; Acetamide,N-[(3S,4R)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)-; BN0549; AKOS022180527; AJ-45617; CC-31938; B6940; FT-0643069; C-35545; BRD-K42679050-001-01-3
Cross-matching ID
PubChem CID
6918184
ChEBI ID
CHEMBL92752
CAS Number
CAS 127408-30-4
TTD Drug ID
D08HFA

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Progesterone-mediated oocyte maturation 1.94 3.31e-2 75/100 (75%) GNAI1;PRKACB;STK10;...
DNA replication 1.89 3.31e-2 34/36 (94.44%) FEN1;RFC3;POLE3;...
Endocrine and other factor-regulated calcium reabsorpti... 1.82 4.78e-2 49/53 (92.45%) GNAS;PRKACB;PRKCA;...
Cell cycle 1.81 4.97e-2 110/124 (88.71%) SMC1A;CCND1;PCNA;...
Hematopoietic cell lineage -1.73 4.07e-2 90/99 (90.91%) MS4A1;IL11RA;IL1A;...
Arginine biosynthesis -1.75 4.12e-2 17/22 (77.27%) GLUD2;CPS1;ARG1;...
Rheumatoid arthritis -1.76 4.05e-2 78/93 (83.87%) IL1A;ATP6V1A;IL18;...
Pertussis -1.77 4.42e-2 64/76 (84.21%) NOD1;IL1A;C4BPA;...
Coronavirus disease -1.78 4.39e-2 215/232 (92.67%) C1S;MMP3;CSF3;...
Staphylococcus aureus infection -1.85 1.37e-2 72/95 (75.79%) KRT20;C1S;KRT10;...
Complement and coagulation cascades -2.10 0.00e+0 76/85 (89.41%) CR1;SERPINA5;CD59;...
Steroid biosynthesis -2.22 0.00e+0 19/20 (95%) NSDHL;SOAT2;CYP51A1;...
Legionellosis -2.24 0.00e+0 51/57 (89.47%) HSPA8;CR1;BNIP3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H