Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMO9XTJ)

Drug Name
Quinelorane Drug Info
Synonyms
Quinelorane; Quinelorane [INN:BAN]; Quineloranum [INN-Latin]; UNII-Z0X4VT3Y1Q; Quinelorano [INN-Spanish]; 97466-90-5; Z0X4VT3Y1Q; LY 163502; LY 137157; LY 175877; CHEMBL155731; (5aR,9aR)-6-propyl-5a,7,8,9,9a,10-hexahydro-5H-pyrido[2,3-g]quinazolin-2-amine; (5aR-trans)-5,5a,6,7,8,9,9a,10-Octahydro-6-propylpyrido(2,3-g)quinazolin-2-amine; Pyrido(2,3-g)quinazolin-2-amine, 5,5a,6,7,8,9,9a,10-octahydro-6-propyl-, (5aR-trans)-; DSSTox_RID_81533; DSSTox_CID_26315; DSSTox_GSID_46315; Quineloranum; Quinelorano; CAS-97466-90-5
Cross-matching ID
PubChem CID
57242
ChEBI ID
CHEMBL155731
CAS Number
CAS 97466-90-5
TTD Drug ID
D0Z2WQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid hormone biosynthesis -1.58 4.93e-2 43/61 (70.49%) AKR1C4;CYP1A2;UGT2B4;...
Cysteine and methionine metabolism -1.59 4.98e-2 43/50 (86%) ADI1;GOT2;MPST;...
PPAR signaling pathway -1.60 4.93e-2 66/74 (89.19%) RXRA;FABP3;SCD5;...
Parkinson disease -1.61 4.56e-2 176/249 (70.68%) VDAC3;COX5B;NDUFB2;...
Porphyrin and chlorophyll metabolism -1.62 4.59e-2 23/43 (53.49%) HCCS;UGT2B4;UGT2B15;...
Metabolism of xenobiotics by cytochrome P450 -1.63 4.38e-2 49/77 (63.64%) CYP1A2;UGT2B4;UGT2B15;...
Nitrogen metabolism -1.64 4.06e-2 16/17 (94.12%) CA4;CA14;GLUL;...
Drug metabolism -1.65 3.85e-2 78/151 (51.66%) TPMT;UGT2B17;XDH;...
Synaptic vesicle cycle -1.66 3.95e-2 63/78 (80.77%) ATP6V1B2;ATP6V0A4;SLC6A13;...
Galactose metabolism -1.66 3.91e-2 26/31 (83.87%) HK2;PFKL;G6PC3;...
Biosynthesis of unsaturated fatty acids -1.66 4.03e-2 21/27 (77.78%) TECR;ELOVL1;ACOT7;...
Complement and coagulation cascades -1.68 3.47e-2 76/85 (89.41%) CR1;SERPINA5;SERPINF2;...
Propanoate metabolism -1.69 3.27e-2 30/34 (88.24%) SUCLG1;ACACB;ECHDC1;...
Collecting duct acid secretion -1.73 1.79e-2 22/27 (81.48%) CLCNKB;ATP6V1B2;ATP6V0A4;...
RNA polymerase -1.76 1.43e-2 23/31 (74.19%) POLR1B;POLR2B;POLR2J;...
Valine, leucine and isoleucine degradation -1.77 1.39e-2 42/48 (87.5%) HSD17B10;MMUT;EHHADH;...
Glycolysis / Gluconeogenesis -1.78 1.18e-2 56/67 (83.58%) ALDH3B1;HK2;LDHB;...
Vibrio cholerae infection -1.78 1.30e-2 44/50 (88%) ATP6V1B2;ATP6V0A4;ATP6V0E2;...
Glyoxylate and dicarboxylate metabolism -1.82 9.27e-3 23/30 (76.67%) CS;ACO2;MMUT;...
Tyrosine metabolism -1.83 9.27e-3 30/36 (83.33%) GOT2;TYR;GSTZ1;...
Fatty acid degradation -1.86 6.62e-3 40/43 (93.02%) CPT2;EHHADH;ECHS1;...
Pentose and glucuronate interconversions -1.88 6.18e-3 17/34 (50%) UGT2B17;RPE;KL;...
Ferroptosis -1.89 7.41e-3 36/41 (87.8%) ATG7;CYBB;NCOA4;...
Pyruvate metabolism -1.90 9.27e-3 41/47 (87.23%) ADH1A;PDHA1;ADH7;...
Citrate cycle (TCA cycle) -1.91 1.24e-2 30/30 (100%) PCK2;PDHB;OGDH;...
Retinol metabolism -2.07 4.63e-3 41/68 (60.29%) CYP1A2;UGT2B4;RDH16;...
Oxidative phosphorylation -2.15 0.00e+0 93/133 (69.92%) ATP6V1B2;NDUFA4;ATP6V0A4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H