General Information of Drug (ID: DMOAOMY)

Drug Name
VLX600 Drug Info
Synonyms GCXMWESEENEVIC-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
6410104
ChEBI ID
CHEMBL4788406
CAS Number
CAS 327031-55-0
TTD Drug ID
D08AAB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
p53 signaling pathway 2.36 0.00e+0 63/73 (86.3%) IGFBP3;DDB2;CDKN1A;...
HIF-1 signaling pathway 2.21 0.00e+0 105/109 (96.33%) ALDOC;SLC2A1;CDKN1A;...
MicroRNAs in cancer 2.20 0.00e+0 146/310 (47.1%) CDKN1A;PDGFA;VEGFA;...
TNF signaling pathway 2.11 0.00e+0 103/112 (91.96%) TNFAIP3;JUNB;IL1B;...
Fructose and mannose metabolism 2.01 4.34e-3 30/33 (90.91%) ALDOC;PFKP;HK2;...
Transcriptional misregulation in cancer 2.01 3.62e-3 158/192 (82.29%) IGFBP3;DDB2;CDKN1A;...
Prostate cancer 1.99 3.10e-3 93/97 (95.88%) TGFA;CDKN1A;PDGFA;...
PI3K-Akt signaling pathway 1.99 2.71e-3 317/354 (89.55%) TGFA;CDKN1A;PDGFA;...
Focal adhesion 1.94 4.82e-3 180/201 (89.55%) PDGFA;FN1;VEGFA;...
Melanoma 1.93 4.34e-3 68/72 (94.44%) DDB2;CDKN1A;PDGFA;...
ECM-receptor interaction 1.91 3.95e-3 80/88 (90.91%) FN1;COL4A1;TNC;...
Bacterial invasion of epithelial cells 1.91 3.62e-3 59/77 (76.62%) FN1;MET;CAV2;...
Small cell lung cancer 1.90 3.34e-3 90/92 (97.83%) DDB2;CDKN1A;FN1;...
AGE-RAGE signaling pathway in diabetic complications 1.90 3.10e-3 97/100 (97%) EGR1;SERPINE1;FN1;...
Relaxin signaling pathway 1.85 5.06e-3 114/129 (88.37%) VEGFA;EGFR;COL4A1;...
Thyroid cancer 1.84 4.75e-3 36/37 (97.3%) DDB2;CDKN1A;GADD45B;...
Bladder cancer 1.84 4.47e-3 40/41 (97.56%) CDKN1A;VEGFA;EGFR;...
Glioma 1.83 6.03e-3 67/75 (89.33%) TGFA;DDB2;CDKN1A;...
Central carbon metabolism in cancer 1.82 7.42e-3 67/70 (95.71%) SLC2A1;PFKP;HK2;...
Pancreatic cancer 1.78 1.14e-2 75/76 (98.68%) TGFA;DDB2;CDKN1A;...
Malaria 1.77 1.39e-2 44/50 (88%) MET;IL1B;CXCL8;...
Axon guidance 1.76 1.43e-2 151/182 (82.97%) EPHA2;MET;BMP7;...
Proteoglycans in cancer 1.76 1.37e-2 172/205 (83.9%) CDKN1A;FN1;VEGFA;...
Colorectal cancer 1.76 1.40e-2 84/86 (97.67%) TGFA;DDB2;CDKN1A;...
African trypanosomiasis 1.75 1.43e-2 32/37 (86.49%) IL1B;FAS;PRKCA;...
Rheumatoid arthritis 1.74 1.67e-2 78/93 (83.87%) VEGFA;IL1B;IL1A;...
TGF-beta signaling pathway 1.74 1.61e-2 81/94 (86.17%) INHBA;TGIF1;ID2;...
Endometrial cancer 1.73 1.70e-2 56/58 (96.55%) DDB2;CDKN1A;GADD45B;...
Non-small cell lung cancer 1.73 1.65e-2 70/72 (97.22%) TGFA;DDB2;CDKN1A;...
Pathways in cancer 1.72 1.82e-2 474/531 (89.27%) TGFA;DDB2;SLC2A1;...
Ascorbate and aldarate metabolism -1.69 2.46e-2 15/30 (50%) KL;AKR1A1;ALDH2;...
Spliceosome -1.75 1.77e-2 101/150 (67.33%) MAGOH;RBMXL2;HSPA1L;...
Folate biosynthesis -1.75 1.97e-2 23/26 (88.46%) MOCS2;ALPG;PCBD1;...
Proteasome -1.78 1.58e-2 44/46 (95.65%) PSMA6;PSMB3;PSMC1;...
Tyrosine metabolism -1.80 1.57e-2 30/36 (83.33%) DCT;HGD;AOC3;...
Pyruvate metabolism -1.82 1.83e-2 41/47 (87.23%) AKR1A1;ME2;ALDH2;...
RNA transport -1.89 5.07e-3 128/186 (68.82%) GEMIN8;EIF2B5;SEC13;...
Fatty acid degradation -1.89 6.34e-3 40/43 (93.02%) EHHADH;ACOX1;ALDH2;...
Citrate cycle (TCA cycle) -1.92 5.63e-3 30/30 (100%) PDHA1;IDH3G;ACO2;...
Ribosome biogenesis in eukaryotes -1.92 4.22e-3 52/108 (48.15%) GTPBP4;NXF1;GNL2;...
Aminoacyl-tRNA biosynthesis -2.05 0.00e+0 15/66 (22.73%) CARS2;IARS2;SARS2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H