Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMOCID7)

Drug Name
Etazolate Drug Info
Synonyms Etazolate hydrochloride; EHT-0202; SQ-20009
Cross-matching ID
PubChem CID
3277
ChEBI ID
CHEMBL356388
CAS Number
CAS 51022-77-6
TTD Drug ID
D0J6LN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Systemic lupus erythematosus 2.13 0.00e+0 45/135 (33.33%) CD40;HLA-DPA1;HLA-DPB1;...
Butanoate metabolism 2.03 6.10e-3 23/28 (82.14%) HMGCS2;HMGCS1;ALDH5A1;...
Intestinal immune network for IgA production 2.02 4.07e-3 38/48 (79.17%) CD40;HLA-DPA1;HLA-DPB1;...
Glycolysis / Gluconeogenesis 2.00 6.10e-3 56/67 (83.58%) PGAM1;PKM;ALDH2;...
Valine, leucine and isoleucine degradation 1.98 4.88e-3 42/48 (87.5%) ALDH2;HMGCS2;HMGCS1;...
Citrate cycle (TCA cycle) 1.94 8.14e-3 30/30 (100%) SUCLG2;PCK1;SUCLA2;...
DNA replication 1.84 1.39e-2 34/36 (94.44%) MCM5;POLE2;MCM2;...
Central carbon metabolism in cancer 1.84 1.22e-2 67/70 (95.71%) SIRT3;PGAM1;PDGFRA;...
Glyoxylate and dicarboxylate metabolism 1.83 1.22e-2 23/30 (76.67%) MMUT;DLD;ACO1;...
Fatty acid elongation 1.80 1.10e-2 19/27 (70.37%) ACAA2;TECR;ECHS1;...
Complement and coagulation cascades 1.80 9.99e-3 76/85 (89.41%) F3;CFH;A2M;...
Synthesis and degradation of ketone bodies 1.78 1.32e-2 9/10 (90%) HMGCS2;HMGCS1;OXCT1;...
Melanoma 1.76 1.41e-2 68/72 (94.44%) PDGFRA;PIK3R3;KRAS;...
Propanoate metabolism 1.73 2.18e-2 30/34 (88.24%) SUCLG2;SUCLA2;MMUT;...
Cell adhesion molecules 1.72 2.44e-2 118/148 (79.73%) VTCN1;CDH2;ALCAM;...
Allograft rejection 1.72 2.44e-2 32/38 (84.21%) CD40;HLA-DPA1;HLA-DPB1;...
Pyrimidine metabolism 1.65 4.81e-2 40/56 (71.43%) DPYD;CDA;ENTPD5;...
Asthma 1.64 4.81e-2 25/31 (80.65%) CD40;HLA-DPA1;HLA-DPB1;...
Mannose type O-glycan biosynthesis 1.64 4.56e-2 14/23 (60.87%) B4GALT2;B4GALT3;B4GAT1;...
Legionellosis -2.09 7.82e-3 51/57 (89.47%) NAIP;IL6;NFKB1;...
IL-17 signaling pathway -2.15 7.82e-3 84/94 (89.36%) IL1B;MAPK6;IL17B;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H