Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMOF7AT)

• Drug Name: Streptozocin Drug Info
• Synonyms: Estreptozocina; STREPTOZOTOCIN; STRZ; Streptozocine; Streptozocinium; Streptozocinum; Streptozosin; Zanosar; Alkylating agent; Binds to DNA; Streptozocinium [Latin]; Streptozocine [INN-French]; Streptozocinum [INN-Latin]; Zanosar (TN); Streptozocin (USAN/INN); Streptozocin, Zanosar, STZ,Streptozotocin;N-(Methylnitrosocarbamoyl)-alpha-D-glucosamine; N-D-Glucosyl-(2)-N'-nitrosomethylharnstoff; N-D-Glucosyl-(2)-N'-nitrosomethylurea; D-Glucose, 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-(9CI); 1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea; 2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-glucopyranose; 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-Deoxy-2[[(methylnitrosoamino)-carbonyl]amino]-D-glucopyranose; 2-deoxy-2-{[methyl(nitroso)carbamoyl]amino}-alpha-D-glucopyranose
• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 29327
  ChEBI ID: CHEMBL9288
  CAS Number: CAS 18883-66-4
  TTD Drug ID: D0I8RR
  ACDINA Drug ID: D01441

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.33	0.00e+0	34/36 (94.44%)	POLE2;PCNA;PRIM1;...
Fanconi anemia pathway	1.81	4.13e-2	36/54 (66.67%)	BLM;RPA3;RMI1;...
Mismatch repair	1.79	4.23e-2	22/23 (95.65%)	PCNA;RPA3;RPA1;...
Propanoate metabolism	1.74	4.83e-2	30/34 (88.24%)	DLD;LDHB;ABAT;...
Fatty acid biosynthesis	1.73	4.44e-2	16/18 (88.89%)	ACSL5;ACSL1;ACACA;...
Cell cycle	1.72	4.44e-2	110/124 (88.71%)	CDC20;PLK1;CDKN1B;...
Viral protein interaction with cytokine and cytokine re...	-1.64	4.88e-2	84/100 (84%)	CCL18;CXCR1;TNFRSF14;...
Renal cell carcinoma	-1.64	4.78e-2	68/69 (98.55%)	NRAS;EGLN2;PDGFB;...
NF-kappa B signaling pathway	-1.65	4.67e-2	90/104 (86.54%)	CCL13;MALT1;NFKBIA;...
Mitophagy	-1.67	4.05e-2	56/68 (82.35%)	MFN1;TBC1D17;UBC;...
Porphyrin and chlorophyll metabolism	-1.68	3.66e-2	23/43 (53.49%)	ALAS1;BLVRA;FECH;...
Cytokine-cytokine receptor interaction	-1.68	3.87e-2	246/295 (83.39%)	TNFSF11;IL6R;GDF5;...
Shigellosis	-1.69	4.01e-2	180/246 (73.17%)	HKDC1;AKT2;HK2;...
Pancreatic cancer	-1.69	4.08e-2	75/76 (98.68%)	GADD45G;SMAD4;PLD2;...
Complement and coagulation cascades	-1.70	4.07e-2	76/85 (89.41%)	KNG1;F9;F13B;...
Chronic myeloid leukemia	-1.71	3.65e-2	72/76 (94.74%)	CDK6;TGFBR2;AKT2;...
Primary immunodeficiency	-1.71	3.93e-2	33/38 (86.84%)	PTPRC;RAG1;AICDA;...
Legionellosis	-1.79	2.13e-2	51/57 (89.47%)	CD14;CASP7;EEF1A2;...
Arginine biosynthesis	-1.81	1.81e-2	17/22 (77.27%)	GPT;ASL;CPS1;...
Rheumatoid arthritis	-1.84	1.28e-2	78/93 (83.87%)	ATP6V1H;HLA-DOB;HLA-DOA;...
Lipid and atherosclerosis	-1.86	1.42e-2	190/215 (88.37%)	LDLR;CD14;CASP7;...
Estrogen signaling pathway	-1.87	1.24e-2	119/137 (86.86%)	NCOA3;CTSD;AKT2;...
Folate biosynthesis	-1.87	1.42e-2	23/26 (88.46%)	TH;TPH1;ALPI;...
TNF signaling pathway	-1.87	1.66e-2	103/112 (91.96%)	LIF;MMP14;MAPK11;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.94	1.14e-2	62/70 (88.57%)	ATP6V1B1;MAPK11;MAPK9;...
Hematopoietic cell lineage	-1.96	1.06e-2	90/99 (90.91%)	FCGR1A;CD2;TFRC;...
IL-17 signaling pathway	-1.99	1.42e-2	84/94 (89.36%)	HSP90AA1;TRAF3IP2;S100A7;...
Antigen processing and presentation	-2.21	0.00e+0	60/78 (76.92%)	NFYA;HLA-DPA1;CANX;...
Protein processing in endoplasmic reticulum	-2.30	0.00e+0	127/171 (74.27%)	EDEM1;MAPK9;CAPN1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM - 20uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Hide ▲

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM - 20uM	6H, 24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM - 20uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼