Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMOFCRY)

• Drug Name: SEROTONIN Drug Info
• Synonyms: serotonin; 5-HYDROXYTRYPTAMINE; 3-(2-Aminoethyl)-1H-indol-5-ol; 50-67-9; Enteramine; 5-HT; Serotonine; Thrombotonin; Thrombocytin; Antemovis; Ds substance; Hippophain; Antemoqua; Substance DS; Substanz DS; 1H-Indol-5-ol, 3-(2-aminoethyl)-; 5-Hta; Tryptamine, 5-hydroxy-; 3-(2-Aminoethyl)indol-5-ol; Enteramin; UNII-333DO1RDJY; Indol-5-ol, 3-(2-aminoethyl)-; 5-Hydroxy-3-(beta-aminoethyl)indole; 3-(beta-Aminoethyl)-5-hydroxyindole; EINECS 200-058-9; 3-(2-Amino-ethyl)-1H-indol-5-ol; BRN 0143524; 333DO1RDJY; CHEBI:28790
• Cross-matching ID:
  PubChem CID: 5202
  ChEBI ID: CHEMBL39
  CAS Number: CAS 50-67-9
  TTD Drug ID: D0F6CD
  VARIDT Drug ID: DR00189
  INTEDE Drug ID: DR1961

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.11	0.00e+0	34/36 (94.44%)	MCM4;PCNA;RPA3;...
Cell cycle	2.11	0.00e+0	110/124 (88.71%)	CDC20;MYC;TFDP1;...
Spliceosome	2.09	0.00e+0	101/150 (67.33%)	LSM6;SRSF1;HNRNPK;...
Progesterone-mediated oocyte maturation	1.85	1.36e-2	75/100 (75%)	CCNA2;PLK1;AURKA;...
Oocyte meiosis	1.76	3.26e-2	90/129 (69.77%)	CDC20;PLK1;AURKA;...
Mitophagy	-1.74	4.74e-2	56/68 (82.35%)	CSNK2A1;BCL2L1;OPTN;...
Amino sugar and nucleotide sugar metabolism	-1.77	3.17e-2	38/48 (79.17%)	HKDC1;PMM1;GMPPA;...
Pentose phosphate pathway	-1.79	3.08e-2	25/30 (83.33%)	ALDOC;TALDO1;PGD;...
Glycerophospholipid metabolism	-1.84	2.03e-2	71/98 (72.45%)	PLPP1;MBOAT7;CDS2;...
Steroid biosynthesis	-1.85	2.31e-2	19/20 (95%)	NSDHL;LIPA;LSS;...
Sphingolipid metabolism	-1.90	9.24e-3	32/49 (65.31%)	CERS4;SPHK1;SPHK2;...
Lysosome	-2.00	4.62e-3	115/128 (89.84%)	M6PR;ARSA;AGA;...
Ferroptosis	-2.13	0.00e+0	36/41 (87.8%)	GCLC;ACSL3;ACSL1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	12uM - 100uM	48H	Hide ▲

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	0.08uM - 100uM	24H, 48H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.08uM - 20uM	24H	Show ▼