General Information of Drug (ID: DMOGFIX)

Drug Name
Eltrombopag Drug Info
Synonyms
Eltrombopag [INN]; SB 497115; SB497115; SB-497115; [1,1'-Biphenyl]-3-carboxylic acid, 3'-[(2Z)-[1-(3,4-dime; Thylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-(9CI); (E)-3\'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2\'-hydroxybiphenyl-3-carboxylic acid
Cross-matching ID
PubChem CID
135449332
ChEBI ID
CHEMBL85010
CAS Number
CAS 496775-61-2
TTD Drug ID
D00PEH
VARIDT Drug ID
DR00908
INTEDE Drug ID
DR0569
ACDINA Drug ID
D00225

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Endocrine and other factor-regulated calcium reabsorpti... 1.97 1.14e-2 49/53 (92.45%) GNAS;ADCY9;PRKACB;...
Vasopressin-regulated water reabsorption 1.93 1.14e-2 40/44 (90.91%) AQP3;GNAS;ADCY9;...
ECM-receptor interaction 1.93 1.14e-2 80/88 (90.91%) AGRN;COL9A3;ITGA3;...
PI3K-Akt signaling pathway 1.90 1.43e-2 317/354 (89.55%) TLR4;PDGFD;EPHA2;...
Human papillomavirus infection 1.90 1.14e-2 284/331 (85.8%) GNAS;COL9A3;ITGA3;...
Central carbon metabolism in cancer 1.89 9.52e-3 67/70 (95.71%) SLC2A1;MET;FGFR3;...
Notch signaling pathway 1.88 9.79e-3 49/59 (83.05%) TLE4;KAT2B;NOTCH2;...
Collecting duct acid secretion 1.88 8.56e-3 22/27 (81.48%) CA2;ATP6V0E2;ATP6V1A;...
Inositol phosphate metabolism 1.85 1.01e-2 66/73 (90.41%) PIK3C2B;PLCB1;SYNJ1;...
Focal adhesion 1.84 1.26e-2 180/201 (89.55%) PDGFD;MET;COL9A3;...
Phosphatidylinositol signaling system 1.83 1.25e-2 82/97 (84.54%) PIK3C2B;PLCB1;CALML5;...
Gastric acid secretion 1.82 1.62e-2 63/76 (82.89%) GNAS;ADCY9;PRKACB;...
mTOR signaling pathway 1.76 2.55e-2 114/154 (74.03%) RPS6KA2;LPIN1;TNFRSF1A;...
Gap junction 1.75 2.94e-2 72/88 (81.82%) GNAS;ADCY9;PDGFD;...
Melanogenesis 1.74 3.04e-2 74/101 (73.27%) GNAS;ADCY9;PRKACB;...
Rap1 signaling pathway 1.74 3.07e-2 184/210 (87.62%) GNAS;ADCY9;PDGFD;...
Sulfur metabolism 1.73 3.09e-2 9/10 (90%) PAPSS2;SELENBP1;SQOR;...
Insulin secretion 1.73 3.04e-2 75/86 (87.21%) GNAS;ADCY9;SLC2A1;...
Proteoglycans in cancer 1.73 2.88e-2 172/205 (83.9%) TLR4;SDC2;PTCH1;...
Pantothenate and CoA biosynthesis 1.72 3.20e-2 14/21 (66.67%) DPYD;COASY;ALDH2;...
Glucagon signaling pathway 1.70 3.70e-2 89/107 (83.18%) GNAS;PPP3CA;SLC2A1;...
Axon guidance 1.69 3.74e-2 151/182 (82.97%) CXCL12;PLXNB2;PPP3CA;...
Regulation of lipolysis in adipocytes 1.69 3.62e-2 52/55 (94.55%) MGLL;GNAS;ADCY9;...
Amoebiasis 1.67 3.73e-2 99/102 (97.06%) TLR4;GNAS;ARG2;...
HIF-1 signaling pathway 1.67 3.76e-2 105/109 (96.33%) TLR4;SLC2A1;ERBB2;...
Long-term potentiation 1.66 3.63e-2 61/67 (91.04%) PPP3CA;RPS6KA2;PRKACB;...
Aldosterone-regulated sodium reabsorption 1.65 3.81e-2 34/37 (91.89%) SCNN1A;ATP1B1;PRKCB;...
Parathyroid hormone synthesis, secretion and action 1.65 3.76e-2 98/106 (92.45%) GNAS;ADCY9;FGFR1;...
Lysosome 1.64 3.78e-2 115/128 (89.84%) CTSC;ABCA2;CTSA;...
Ras signaling pathway 1.63 3.83e-2 201/232 (86.64%) PDGFD;EPHA2;MET;...
Cell cycle -1.60 4.80e-2 110/124 (88.71%) MDM2;PKMYT1;CCNH;...
Complement and coagulation cascades -1.61 4.60e-2 76/85 (89.41%) FGG;SERPINA1;PLG;...
PPAR signaling pathway -1.64 3.75e-2 66/74 (89.19%) SCD5;ACSL3;PLIN1;...
Nucleotide excision repair -1.68 2.94e-2 40/47 (85.11%) POLE3;RFC5;GTF2H4;...
Huntington disease -1.75 1.46e-2 233/306 (76.14%) GRIA4;COX6C;GPX3;...
Legionellosis -1.77 1.52e-2 51/57 (89.47%) HSPA6;PYCARD;NAIP;...
Cholesterol metabolism -1.78 1.51e-2 44/50 (88%) CD36;LIPG;ABCG5;...
Amyotrophic lateral sclerosis -1.79 1.19e-2 267/364 (73.35%) NXT2;PSMD8;NDUFS4;...
Vitamin digestion and absorption -1.83 7.92e-3 17/24 (70.83%) SCARB1;APOA1;APOB;...
IL-17 signaling pathway -1.83 8.91e-3 84/94 (89.36%) IKBKE;FADD;SRSF1;...
Spliceosome -1.84 1.02e-2 101/150 (67.33%) LSM5;DDX46;CTNNBL1;...
Ribosome biogenesis in eukaryotes -1.89 6.60e-3 52/108 (48.15%) GNL3;MDN1;LSG1;...
DNA replication -1.97 1.58e-3 34/36 (94.44%) MCM4;MCM7;POLE3;...
Folate biosynthesis -2.14 1.98e-3 23/26 (88.46%) PTS;TH;TPH1;...
Proteasome -2.19 0.00e+0 44/46 (95.65%) PSMC5;PSMD9;PSMA7;...
RNA transport -2.21 0.00e+0 128/186 (68.82%) NUP133;MAGOH;NUP107;...
Ribosome -2.31 0.00e+0 113/158 (71.52%) MRPS11;RPS20;RPS10;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H