Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMOI9EL)

Drug Name
Radezolid Drug Info
Synonyms
Radezolid; Radezolid hydrochloride; RX-103; RX-1741; RX-01-667; Oxazolidinone antibiotic (bacterial infection), Rib-X Pharmaceuticals; Oxazolidinone antibiotic (CAP/uSSSI), Rib-X Pharamceuticals; Radezolid (iv, gram positive bacterial infection), Rib-X Pharmaceuticals; RX-1741 (iv, gram positive bacterial infection), Rib-X Pharmaceuticals; Radezolid (oral, CAP/uSSSI), Rib-X Pharmaceuticals; RX-1741 (oral, CAP/uSSSI), Rib-X Pharmaceuticals
Cross-matching ID
PubChem CID
11224409
TTD Drug ID
D0W5PN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mismatch repair 2.08 2.63e-2 22/23 (95.65%) PCNA;MLH1;MSH2;...
Ribosome biogenesis in eukaryotes 1.89 4.61e-2 52/108 (48.15%) NOP56;IMP4;LSG1;...
Alanine, aspartate and glutamate metabolism 1.84 4.83e-2 27/37 (72.97%) ASNS;ASS1;CAD;...
DNA replication 1.84 3.62e-2 34/36 (94.44%) PCNA;RNASEH1;MCM6;...
Pentose phosphate pathway 1.83 2.90e-2 25/30 (83.33%) PGD;TKT;G6PD;...
AGE-RAGE signaling pathway in diabetic complications 1.83 2.41e-2 97/100 (97%) COL1A2;VEGFA;PLCB4;...
Complement and coagulation cascades -1.76 3.70e-2 76/85 (89.41%) CR1;C8B;CFH;...
Mineral absorption -1.83 3.26e-2 48/60 (80%) ATP2B1;ATP2B4;VDR;...
Oxidative phosphorylation -2.05 0.00e+0 93/133 (69.92%) COX8A;ATP5MF;ATP5PB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H