Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMOIX5S)

• Drug Name: Azilsartan Drug Info
• Synonyms: TAK 536; TAK-536; Azilsartan (INN/USAN)
• Cross-matching ID:
  PubChem CID: 135415867
  ChEBI ID: CHEMBL68850
  CAS Number: CAS 147403-03-0
  TTD Drug ID: D05FGG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
IL-17 signaling pathway	2.33	0.00e+0	84/94 (89.36%)	CXCL8;LCN2;MMP9;...
Viral protein interaction with cytokine and cytokine re...	2.15	0.00e+0	84/100 (84%)	CXCL8;CXCL13;CCL5;...
Primary immunodeficiency	2.00	3.15e-3	33/38 (86.84%)	CD3D;IL7R;LCK;...
NF-kappa B signaling pathway	1.90	4.73e-3	90/104 (86.54%)	CXCL8;LYN;LTB;...
NOD-like receptor signaling pathway	1.83	1.70e-2	145/181 (80.11%)	CXCL8;CCL5;IKBKE;...
Toll-like receptor signaling pathway	1.71	4.97e-2	94/104 (90.38%)	CXCL8;CTSK;CCL5;...
Fc gamma R-mediated phagocytosis	1.70	4.73e-2	79/97 (81.44%)	LYN;PLA2G4A;RPS6KB1;...
Cytosolic DNA-sensing pathway	1.70	4.26e-2	52/63 (82.54%)	CCL5;IKBKE;AIM2;...
Chemokine signaling pathway	1.68	4.39e-2	163/192 (84.9%)	CXCL8;CXCL13;LYN;...
Dilated cardiomyopathy	-1.77	4.98e-2	86/96 (89.58%)	AGT;DMD;MYH6;...
Ribosome	-1.84	1.40e-2	113/158 (71.52%)	RPL37A;RPSA;RPLP0;...
Glutathione metabolism	-1.85	2.10e-2	43/57 (75.44%)	GPX4;IDH1;PGD;...
Cardiac muscle contraction	-1.86	4.19e-2	64/87 (73.56%)	CACNA1S;SLC9A6;COX5A;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲