Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMOLNCZ)

• Drug Name: ACECLIDINE Drug Info
• Synonyms: (-)-aceclidine; R-(-)-aceclidine; GTPL288; ZB016005; [(8R)-1-azoniabicyclo[2.2.2]octan-8-yl] acetate
• Cross-matching ID:
  PubChem CID: 1979
  ChEBI ID: CHEMBL20835
  CAS Number: CAS 827-61-2
  TTD Drug ID: D0R7WU

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
TNF signaling pathway	-1.84	3.66e-2	103/112 (91.96%)	PIK3CD;MAPK3;TNFRSF1A;...
Pentose and glucuronate interconversions	-1.87	3.30e-2	17/34 (50%)	AKR1B10;AKR1B1;UGP2;...
Inositol phosphate metabolism	-2.02	0.00e+0	66/73 (90.41%)	PIK3C2B;PIK3C2A;MTMR6;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼