General Information of Drug (ID: DMOLNHF)

Drug Name
Melphalan Drug Info
Synonyms
Alkeran; Levofalan; Levofolan; Levopholan; Melfalan; Melfalano; Melphalanum; Alanine Nitrogen Mustard; Phenylalanine mustard; Phenylalanine nitrogen mu stard; Phenylalanine nitrogen mustard; AY3360000; CB 3025; ALKERAN (TN); Alkeran (TN); At-290; CB-3025; L-PAM; L-Phenylalanine mustard; L-Sarcolysin; L-Sarcolysine; L-Sarkolysin; Melfalano [INN-Spanish]; Melphalanum [INN-Latin]; SK-15673; TRANSGENIC MODEL EVALUATION (MELPHALAN); MELPHALAN (SEE ALSO TRANSGENIC MODEL EVALUATION (MELPHALAN)); P-L-Sarcolysin; P-L-sarcolysine; TRANSGENIC LEP (MELPHALAN) (SEE ALSO MELPHALAN); Melphalan (JP15/USP/INN); Melphalan [USAN:INN:BAN:JAN]; P-Bis(beta-chloroethyl)aminophenylalanine; P-N-Di(chloroethyl)aminophenylalanine; P-N-di(chloroethyl)aminophenylala nine; P-Di-(2-chloroethyl)amino-L-phenylalanine; P-N-Bis(2-chloroethyl)amino-L-phenylalanine; L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine; L-3-(para-(Bis(2-chloroethyl)amino)phenyl)alanine; P-N,N-bis(2-chloroethyl)amino-L-phenylalanine; (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid; (2s)-2-amino-3-(4-[bis(2-chloroethyl)amino]phenyl)propanoic acid; 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine; 3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine; 3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine; 4-(Bis(2-chloroethyl)amino)-L-phenylalanine; 4-[Bis(2-chloroethyl)amino]-L-phenylalanine; 4-[Bis-(2-chloroethyl)amino]-L-phenylalanine
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
460612
ChEBI ID
CHEMBL852
CAS Number
CAS 148-82-3
TTD Drug ID
D00FGO
VARIDT Drug ID
DR00379
INTEDE Drug ID
DR1021
ACDINA Drug ID
D00394

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Influenza A 2.49 0.00e+0 156/172 (90.7%) TLR4;OAS1;MX2;...
p53 signaling pathway 2.30 0.00e+0 63/73 (86.3%) CDKN1A;DDB2;FAS;...
Hepatitis C 2.24 0.00e+0 139/157 (88.54%) IFIT1;CDKN1A;OAS1;...
Graft-versus-host disease 2.21 0.00e+0 32/42 (76.19%) FAS;HLA-B;HLA-C;...
Epstein-Barr virus infection 2.14 0.00e+0 189/202 (93.56%) CDKN1A;LYN;OAS1;...
Toll-like receptor signaling pathway 2.07 1.68e-3 94/104 (90.38%) TLR4;TICAM1;CXCL11;...
Measles 2.03 1.44e-3 133/139 (95.68%) TLR4;OAS1;MX2;...
Viral myocarditis 2.02 1.26e-3 53/60 (88.33%) HLA-B;HLA-C;HLA-F;...
Necroptosis 2.01 1.12e-3 113/159 (71.07%) TLR4;TICAM1;TNFAIP3;...
Herpes simplex virus 1 infection 2.00 1.01e-3 165/498 (33.13%) OAS1;TICAM1;BST2;...
Type I diabetes mellitus 1.99 9.18e-4 38/43 (88.37%) FAS;HLA-B;HLA-C;...
NF-kappa B signaling pathway 1.98 8.41e-4 90/104 (86.54%) TLR4;LYN;PTGS2;...
NOD-like receptor signaling pathway 1.96 7.76e-4 145/181 (80.11%) TLR4;OAS1;TICAM1;...
Cytosolic DNA-sensing pathway 1.96 7.21e-4 52/63 (82.54%) CXCL10;PYCARD;IRF7;...
Toxoplasmosis 1.89 2.69e-3 103/112 (91.96%) TLR4;STAT1;LY96;...
Inflammatory bowel disease 1.89 2.52e-3 58/65 (89.23%) TLR4;STAT1;IL18;...
Allograft rejection 1.89 2.38e-3 32/38 (84.21%) FAS;HLA-B;HLA-C;...
Rheumatoid arthritis 1.88 2.24e-3 78/93 (83.87%) TLR4;ATP6V1D;LTB;...
Leishmaniasis 1.85 4.78e-3 67/77 (87.01%) TLR4;PTGS2;STAT1;...
Viral protein interaction with cytokine and cytokine re... 1.85 4.54e-3 84/100 (84%) CXCL11;CXCL10;TNFSF10;...
Hepatitis B 1.83 4.81e-3 151/162 (93.21%) TLR4;CDKN1A;CASP10;...
RIG-I-like receptor signaling pathway 1.81 7.34e-3 64/70 (91.43%) CASP10;CXCL10;ISG15;...
Kaposi sarcoma-associated herpesvirus infection 1.79 1.01e-2 172/193 (89.12%) CDKN1A;LYN;CLEC2B;...
Apoptosis 1.78 9.67e-3 126/168 (75%) CASP10;FAS;CTSS;...
Salmonella infection 1.78 9.69e-3 198/249 (79.52%) TLR4;MYO6;TNFSF10;...
Mismatch repair 1.78 9.32e-3 22/23 (95.65%) RFC2;LIG1;MLH1;...
Cytokine-cytokine receptor interaction 1.78 9.35e-3 246/295 (83.39%) LTB;CXCL11;FAS;...
DNA replication 1.77 9.73e-3 34/36 (94.44%) RFC2;LIG1;FEN1;...
Nucleotide excision repair 1.76 1.04e-2 40/47 (85.11%) DDB2;CETN2;RFC2;...
Thyroid cancer 1.74 1.11e-2 36/37 (97.3%) CDKN1A;DDB2;CDH1;...
Circadian entrainment -1.69 4.35e-2 85/97 (87.63%) CACNA1I;PLCB3;GNG11;...
Glutamatergic synapse -1.69 4.83e-2 97/114 (85.09%) ADCY2;ADCY9;GNAQ;...
Protein digestion and absorption -1.71 4.45e-2 78/103 (75.73%) MME;SLC1A5;FXYD2;...
Salivary secretion -1.74 3.95e-2 76/93 (81.72%) HTN3;ADCY2;ADCY9;...
Cortisol synthesis and secretion -1.75 3.79e-2 58/65 (89.23%) GNA11;ADCY2;ADCY9;...
Amphetamine addiction -1.76 4.35e-2 57/69 (82.61%) PPP3CA;CALML3;CACNA1D;...
Melanogenesis -1.77 4.20e-2 74/101 (73.27%) EP300;KRAS;DVL2;...
Aldosterone synthesis and secretion -1.88 1.32e-2 85/98 (86.73%) CALML3;CACNA1D;PLCB4;...
Nitrogen metabolism -1.92 4.94e-3 16/17 (94.12%) GLUL;CA8;GLUD2;...
Insulin secretion -1.96 9.88e-3 75/86 (87.21%) GNA11;ADCYAP1;CAMK2G;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.08uM - 20uM 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.08uM - 20uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H