Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMOM8AL)

• Drug Name: Scopolamine Drug Info
• Synonyms: Atroscine; Euscopol; Hyosceine; Hysco; Isoscopil; Kwells; SEE; Scop; Scopamin; Scopolaminhydrobromid; Scopos; Sereen; Tranaxine; Transcop; Triptone; Atroscine Hydrobromide; Hydroscine hydrobromide; Hyocine F hydrobromide; Hyoscine bromide; Hyoscyine hydrobromide; SCOPOLAMINE BROMIDE; Scopolamine Hyoscine; Scopolaminium bromide; Scopolammonium bromide; Tropane alkaloid; MOLI001381; NCI61806; Borrachero (TN); Burundanga (TN); Hyoscine (TN); L-Hyoscine hydrobromide; Scopoderm-TTS; Scopolamine (INN); Transderm scop (TN); Levo-duboisine (TN); Xy-, (-)-tropate (ester); (-)-Scopolamine hydrobromide trihydrate; 1alphaH,5alphaH-Tropan-3alpha-ol, 6beta,7beta-epo; 1alphaH,5alphaH-Tropan-3alpha-ol, 6beta,7beta-epoxy-, (-)-tropate (ester); 3-Oxa-9-azatricyclo(3.3.1.O(sup 2,4))nonan-7-ol, 9-methyl-, tropate (ester); 9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]non-7-yl tropate
• Therapeutic Class: Antispasmodics
• Cross-matching ID:
  PubChem CID: 3000322
  ChEBI ID: CHEMBL16794
  CAS Number: CAS 114-49-8
  TTD Drug ID: D0B7YT
  VARIDT Drug ID: DR01000

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Alanine, aspartate and glutamate metabolism	-1.63	4.08e-2	27/37 (72.97%)	GLS2;ASS1;ASNS;...
Adrenergic signaling in cardiomyocytes	-1.65	3.94e-2	130/150 (86.67%)	PPP2R3B;ATP2B1;ATF4;...
Butanoate metabolism	-1.65	4.00e-2	23/28 (82.14%)	HMGCS1;BDH2;ACAT2;...
Steroid hormone biosynthesis	-1.68	3.30e-2	43/61 (70.49%)	CYP1B1;AKR1C4;STS;...
Synthesis and degradation of ketone bodies	-1.68	3.38e-2	9/10 (90%)	HMGCS1;BDH2;ACAT2;...
Peroxisome	-1.69	3.08e-2	72/82 (87.8%)	CAT;ACSL5;ACOX1;...
PPAR signaling pathway	-1.72	2.26e-2	66/74 (89.19%)	PPARA;PLIN2;FABP3;...
Phenylalanine metabolism	-1.72	2.30e-2	14/17 (82.35%)	ALDH3A1;ALDH3B1;GLYAT;...
GABAergic synapse	-1.75	1.86e-2	76/89 (85.39%)	GABRB1;SRC;GLS2;...
Cholesterol metabolism	-1.76	1.61e-2	44/50 (88%)	ANGPTL8;LIPC;ABCG5;...
Histidine metabolism	-1.77	1.69e-2	16/22 (72.73%)	FTCD;CNDP2;ALDH3A1;...
Ferroptosis	-1.78	1.52e-2	36/41 (87.8%)	NCOA4;VDAC3;ALOX15;...
Retinol metabolism	-1.78	1.54e-2	41/68 (60.29%)	CYP26B1;ALDH1A1;CYP2C8;...
Collecting duct acid secretion	-1.79	1.49e-2	22/27 (81.48%)	ATP6V1C1;ATP6V0C;SLC4A1;...
Glyoxylate and dicarboxylate metabolism	-1.81	1.43e-2	23/30 (76.67%)	GLDC;AGXT;MDH2;...
Bile secretion	-1.83	1.28e-2	68/90 (75.56%)	PRKACB;ABCB1;SLC22A7;...
Aldosterone-regulated sodium reabsorption	-1.84	1.38e-2	34/37 (91.89%)	SFN;KCNJ1;ATP1B4;...
Thyroid hormone synthesis	-1.85	1.30e-2	66/75 (88%)	DUOX2;ASGR2;ATP1B1;...
Proximal tubule bicarbonate reclamation	-1.86	1.40e-2	21/23 (91.3%)	SLC4A4;ATP1B2;MDH1;...
Synaptic vesicle cycle	-1.88	1.20e-2	63/78 (80.77%)	TCIRG1;CLTCL1;UNC13B;...
Mitophagy	-1.89	1.20e-2	56/68 (82.35%)	TBC1D17;ATF4;MRAS;...
Arginine and proline metabolism	-1.90	1.07e-2	39/50 (78%)	SMS;PRODH2;P4HA2;...
Vibrio cholerae infection	-1.97	6.02e-3	44/50 (88%)	SEC61A1;PRKACA;ATP6AP1;...
Nitrogen metabolism	-1.99	5.16e-3	16/17 (94.12%)	CA3;GLUD1;CA12;...
Metabolism of xenobiotics by cytochrome P450	-2.05	4.01e-3	49/77 (63.64%)	CYP1B1;MGST3;ALDH3A1;...
Staphylococcus aureus infection	-2.06	4.82e-3	72/95 (75.79%)	C5AR1;MBL2;CFI;...
Arginine biosynthesis	-2.07	6.02e-3	17/22 (77.27%)	GLUD2;OTC;ASL;...
Estrogen signaling pathway	-2.08	4.01e-3	119/137 (86.86%)	CTSD;SOS1;HSP90B1;...
Drug metabolism	-2.14	0.00e+0	78/151 (51.66%)	HPRT1;FMO5;NAT2;...
Complement and coagulation cascades	-2.34	0.00e+0	76/85 (89.41%)	CLU;FGG;C8A;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	10uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼