General Information of Drug (ID: DMOPCBD)

Drug Name
UNC1999 Drug Info
Synonyms UNC 1999; UNC-1999
Cross-matching ID
PubChem CID
72551585
ChEBI ID
CHEMBL3414619
CAS Number
CAS 1431612-23-5
TTD Drug ID
D02YXP

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.49 0.00e+0 19/20 (95%) MSMO1;SQLE;DHCR7;...
Terpenoid backbone biosynthesis 2.06 1.04e-2 18/22 (81.82%) HMGCS1;IDI1;FDPS;...
PPAR signaling pathway 2.03 6.96e-3 66/74 (89.19%) HMGCS1;SCD;DBI;...
Biosynthesis of unsaturated fatty acids 1.94 1.31e-2 21/27 (77.78%) SCD;FADS1;FADS2;...
Lysosome 1.90 1.67e-2 115/128 (89.84%) NPC1;LIPA;LITAF;...
Fructose and mannose metabolism 1.89 1.57e-2 30/33 (90.91%) ALDOC;HK2;PFKP;...
HIF-1 signaling pathway 1.89 1.64e-2 105/109 (96.33%) ALDOC;VEGFA;HMOX1;...
Starch and sucrose metabolism 1.87 1.44e-2 25/36 (69.44%) HK2;ENPP1;MGAM;...
Synaptic vesicle cycle 1.86 1.39e-2 63/78 (80.77%) SLC1A1;STX3;ATP6V1G1;...
Glycolysis / Gluconeogenesis 1.81 2.51e-2 56/67 (83.58%) ALDOC;HK2;ENO2;...
Rheumatoid arthritis 1.76 4.27e-2 78/93 (83.87%) VEGFA;MMP3;CCL20;...
Synthesis and degradation of ketone bodies 1.75 4.35e-2 9/10 (90%) HMGCS1;ACAT2
Legionellosis 1.74 4.34e-2 51/57 (89.47%) BNIP3;HSPA1A;HSPA6;...
Cholesterol metabolism 1.74 4.25e-2 44/50 (88%) LDLR;NPC1;VDAC1;...
Galactose metabolism 1.74 3.97e-2 26/31 (83.87%) HK2;PFKP;GLA;...
Vibrio cholerae infection 1.73 3.85e-2 44/50 (88%) SLC12A2;ATP6V1G1;ATP6V0E1;...
DNA replication -1.74 4.16e-2 34/36 (94.44%) RFC1;POLD2;PRIM2;...
Fanconi anemia pathway -1.80 3.13e-2 36/54 (66.67%) FANCC;FAAP24;FANCA;...
Spliceosome -1.85 1.69e-2 101/150 (67.33%) DHX38;CDC40;DDX23;...
Nucleotide excision repair -1.91 1.41e-2 40/47 (85.11%) POLE;ERCC5;DDB1;...
RNA polymerase -1.92 1.25e-2 23/31 (74.19%) POLR1E;POLR3D;POLR1D;...
Mismatch repair -1.95 1.88e-2 22/23 (95.65%) RFC5;RPA3;POLD1;...
Ribosome -2.50 0.00e+0 113/158 (71.52%) RPL7;RPS15A;RPL12;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H