Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMOQ81Y)

Drug Name
Vernakalant Drug Info
Synonyms
Vernakalant; 794466-70-9; UNII-9G468C8B13; Vemakalant; RSD1235; 9G468C8B13; (3R)-1-((1R,2R)-2-(2-(3,4-dimethoxyphenyl)ethoxy)cyclohexyl)pyrrolidin-3-ol; 3-Pyrrolidinol,1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]-, (3R)-; RSD-1235; Vernakalant [INN:BAN]; SCHEMBL410062; CHEMBL2111112; DTXSID60229659; VBHQKCBVWWUUKN-KZNAEPCWSA-N; CHEBI:135956; EX-A2465; ZINC22010910; 4151AH; AKOS027326205; DB06217; SB16873; CS-0276; API0014187; RL05068; 3-Pyrrolidinol, 1-((1R,2R)-2-(2-(3,4-dimethoxyphenyl)ethoxy)cyclohexyl)-, (3R)-
Cross-matching ID
PubChem CID
9930049
ChEBI ID
CHEMBL135956
CAS Number
CAS 794466-70-9
TTD Drug ID
D00OTL
INTEDE Drug ID
DR1682

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Valine, leucine and isoleucine degradation 2.16 0.00e+0 42/48 (87.5%) HMGCS2;ALDH6A1;ACAA1;...
Metabolism of xenobiotics by cytochrome P450 1.93 5.82e-3 49/77 (63.64%) ALDH3A1;EPHX1;CYP2E1;...
Phosphatidylinositol signaling system 1.87 1.94e-2 82/97 (84.54%) PLCE1;ITPR1;PLCB1;...
Pentose phosphate pathway 1.86 1.75e-2 25/30 (83.33%) PFKL;PFKM;PGD;...
Citrate cycle (TCA cycle) 1.83 2.56e-2 30/30 (100%) DLST;PDHA1;SUCLG2;...
Glycolysis / Gluconeogenesis 1.82 2.52e-2 56/67 (83.58%) ALDH3A1;PFKL;PFKM;...
Peroxisome 1.81 2.16e-2 72/82 (87.8%) ACAA1;PRDX1;AMACR;...
Biosynthesis of unsaturated fatty acids 1.78 3.64e-2 21/27 (77.78%) HACD1;HACD3;ACAA1;...
Glyoxylate and dicarboxylate metabolism 1.74 4.27e-2 23/30 (76.67%) GLDC;PCCB;AMT;...
Central carbon metabolism in cancer 1.72 4.42e-2 67/70 (95.71%) SLC2A1;FGFR3;PFKL;...
Galactose metabolism 1.72 4.02e-2 26/31 (83.87%) PFKL;PFKM;B4GALT1;...
Synthesis and degradation of ketone bodies 1.71 4.27e-2 9/10 (90%) HMGCS2;HMGCS1;HMGCL;...
D-Glutamine and D-glutamate metabolism 1.68 4.89e-2 5/5 (100%) GLUD2;GLUD1;DGLUCY
IL-17 signaling pathway -1.85 1.50e-2 84/94 (89.36%) MMP1;MAPK7;MMP9;...
Viral protein interaction with cytokine and cytokine re... -1.88 1.21e-2 84/100 (84%) CX3CL1;CCR10;IL10RA;...
TNF signaling pathway -1.91 1.13e-2 103/112 (91.96%) BCL3;DNM1L;CCL2;...
Epithelial cell signaling in Helicobacter pylori infect... -1.95 6.07e-3 62/70 (88.57%) NFKB1;PTPN11;HBEGF;...
Rheumatoid arthritis -1.95 8.09e-3 78/93 (83.87%) MMP1;TCIRG1;CSF2;...
Cytokine-cytokine receptor interaction -1.95 1.21e-2 246/295 (83.39%) TNFRSF11B;CX3CL1;BMP5;...
Legionellosis -2.10 8.09e-3 51/57 (89.47%) HSPA2;HSPA6;IL1B;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 3.33uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H