Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMOQJZC)

Drug Name
Bisindolylmaleimide-I Drug Info
Synonyms
Bisindolylmaleimide i; bisindolylmaleimide i; 133052-90-1; GF 109203X; GF109203X; Go 6850; GF-109203X; RBT205 INHIBITOR; Go-6850; UNII-L79H6N0V6C; 6850; Bisindolylmaleimide I (GF 109203X); CHEMBL7463; 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE; 3-(1-(3-(Dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione; L79H6N0V6C; QMGUOJYZJKLOLH-UHFFFAOYSA-N; 2-[1-(3-dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl)maleimide; GF-109203; Go6850
Cross-matching ID
PubChem CID
2396
ChEBI ID
CHEMBL7463
CAS Number
CAS 133052-90-1
TTD Drug ID
D0TO6S
VARIDT Drug ID
DR00622

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.57 0.00e+0 19/20 (95%) MSMO1;SQLE;DHCR24;...
Ribosome 2.37 0.00e+0 113/158 (71.52%) RPS4Y1;MRPL17;MRPL15;...
Biosynthesis of unsaturated fatty acids 2.07 2.56e-3 21/27 (77.78%) SCD;FADS2;FADS1;...
DNA replication 2.06 1.92e-3 34/36 (94.44%) FEN1;PCNA;MCM4;...
PPAR signaling pathway 2.01 1.53e-3 66/74 (89.19%) HMGCS1;SCD;FADS2;...
Terpenoid backbone biosynthesis 1.98 1.28e-3 18/22 (81.82%) HMGCS1;IDI1;ACAT2;...
Fatty acid elongation 1.85 8.76e-3 19/27 (70.37%) ELOVL6;ACOT7;HACD1;...
Butanoate metabolism 1.80 1.15e-2 23/28 (82.14%) HMGCS1;ACAT2;ACAT1;...
Pantothenate and CoA biosynthesis 1.78 1.36e-2 14/21 (66.67%) PANK3;COASY;DPYS;...
Synthesis and degradation of ketone bodies 1.76 1.30e-2 9/10 (90%) HMGCS1;ACAT2;ACAT1;...
Arginine biosynthesis 1.75 1.18e-2 17/22 (77.27%) ASS1;ARG1;GLUD2;...
Ribosome biogenesis in eukaryotes 1.75 1.09e-2 52/108 (48.15%) NXT1;DKC1;IMP3;...
One carbon pool by folate 1.74 1.06e-2 15/20 (75%) SHMT2;MTHFD2;TYMS;...
Drug metabolism 1.74 1.04e-2 78/151 (51.66%) ADH1B;IMPDH2;NME1;...
Fatty acid biosynthesis 1.73 9.71e-3 16/18 (88.89%) FASN;MCAT;ACSBG1;...
Fatty acid degradation 1.73 1.05e-2 40/43 (93.02%) ACAT2;ADH1B;ACAT1;...
Alanine, aspartate and glutamate metabolism 1.68 1.89e-2 27/37 (72.97%) ASS1;CAD;ALDH4A1;...
p53 signaling pathway 1.67 2.04e-2 63/73 (86.3%) DDB2;CDKN1A;THBS1;...
RNA transport 1.63 3.03e-2 128/186 (68.82%) EEF1A2;EIF2S1;NXT1;...
Vitamin digestion and absorption 1.61 4.03e-2 17/24 (70.83%) APOA1;APOB;SCARB1;...
Metabolism of xenobiotics by cytochrome P450 1.60 4.09e-2 49/77 (63.64%) ADH1B;AKR7A3;GSTM3;...
Oxidative phosphorylation 1.59 3.97e-2 93/133 (69.92%) ATP6AP1;ATP6V1D;NDUFB1;...
Cholesterol metabolism 1.59 3.87e-2 44/50 (88%) LDLR;APOC3;APOA1;...
Pyrimidine metabolism 1.59 3.83e-2 40/56 (71.43%) PNP;NME1;CAD;...
Fat digestion and absorption 1.59 3.68e-2 35/43 (81.4%) ACAT2;APOA1;APOB;...
Bacterial invasion of epithelial cells -1.81 2.40e-2 59/77 (76.62%) PIK3R3;ARHGAP10;DNM3;...
FoxO signaling pathway -1.81 2.74e-2 118/131 (90.08%) MAP2K1;TGFB2;FOXO3;...
Focal adhesion -1.82 2.60e-2 180/201 (89.55%) MAP2K1;PIP5K1C;DIAPH1;...
Inositol phosphate metabolism -1.84 1.92e-2 66/73 (90.41%) MTMR3;ALDH6A1;MINPP1;...
Natural killer cell mediated cytotoxicity -1.92 1.20e-2 99/131 (75.57%) PRKCB;IFNGR1;NCR3;...
Amoebiasis -1.96 3.99e-3 99/102 (97.06%) LAMB2;PIK3CA;LAMA1;...
Primary immunodeficiency -1.97 5.99e-3 33/38 (86.84%) ICOS;ADA;IGLL1;...
TNF signaling pathway -2.08 0.00e+0 103/112 (91.96%) CASP7;JUN;EDN1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 12uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 12uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 12uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 12uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 12uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 12uM 6H
MDST8 CVCL_1400 Homo sapiens 12uM 6H
NCI-H508 CVCL_1561 Homo sapiens 12uM 6H
SNU-1040 CVCL_5001 Homo sapiens 12uM 6H
SNU-C4 CVCL_5008 Homo sapiens 12uM 6H
SNU-C5 CVCL_5009 Homo sapiens 12uM 6H
SW480 CVCL_0546 Homo sapiens 12uM 6H
SW620 CVCL_0547 Homo sapiens 12uM 6H
SW948 CVCL_0550 Homo sapiens 12uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 12uM 6H
HT115 CVCL_1294 Homo sapiens 12uM 6H
RKO CVCL_0504 Homo sapiens 12uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 12uM 6H
SNG-M CVCL_1707 Homo sapiens 12uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 12uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 12uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 12uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 12uM 6H, 24H, 48H
DV-90 CVCL_1184 Homo sapiens 12uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 12uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 12uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 12uM 6H
T3M-10 CVCL_1729 Homo sapiens 12uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 12uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 12uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM - 12uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 12uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 12uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 12uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 12uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 12uM 6H
OV7 CVCL_1623 Homo sapiens 12uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 12uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 12uM 6H
RMUG-S CVCL_1666 Homo sapiens 12uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 12uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 12uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 12uM 6H
PL-21 CVCL_2161 Homo sapiens 12uM 6H
SKM-1 CVCL_0010 Homo sapiens 12uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 12uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 12uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM - 12uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 12uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 12uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 12uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 12uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H