Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMOTQRI)

Drug Name
Diloxanide Drug Info
Synonyms
Entamide; Diloxanid; Amebamida; Ame-boots; 579-38-4; 2,2-Dichloro-N-(4-hydroxyphenyl)-N-methylacetamide; Diloxanidum [INN-Latin]; Diloxanida [INN-Spanish]; Acetamide, 2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl-; Diloxanide [INN:BAN:DCF]; UNII-89134SCM7M; RD 3803; B 4453; EINECS 209-439-4; C9H9Cl2NO2; BRN 2840273; 2,2-Dichloro-4'-hydroxy-N-methylacetanilide; 89134SCM7M; ACETANILIDE, 2,2-DICHLORO-4'-HYDROXY-N-METHYL-; Diloxanida; Diloxanidum; Diloxamide; Diloxanide (INN); 2,2-Dichlor-4'-hydroxy-N-methylacetanilid
Cross-matching ID
PubChem CID
11367
CAS Number
CAS 579-38-4
TTD Drug ID
D02WAB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Staphylococcus aureus infection 1.99 0.00e+0 72/95 (75.79%) KRT23;DEFB1;CFD;...
Nicotinate and nicotinamide metabolism -1.72 4.27e-2 25/35 (71.43%) NT5C2;NNT;SIRT5;...
AGE-RAGE signaling pathway in diabetic complications -1.76 3.01e-2 97/100 (97%) CYBB;PLCG1;COL4A5;...
NOD-like receptor signaling pathway -1.79 2.65e-2 145/181 (80.11%) CCL2;JAK1;IFI16;...
Ribosome -1.80 3.24e-2 113/158 (71.52%) RPL19;RPS25;RPSA;...
RIG-I-like receptor signaling pathway -1.86 2.65e-2 64/70 (91.43%) IFNB1;MAP3K1;ATG12;...
NF-kappa B signaling pathway -1.98 0.00e+0 90/104 (86.54%) PRKCQ;BIRC2;EDA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 6.66uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H