Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMOV0AP)

Drug Name
842166X Drug Info
Synonyms
GW842166X; 666260-75-9; GW 842166X; GW-842166X; UNII-VL1I6P2DZ8; VL1I6P2DZ8; GW842166; GW 842166; CHEMBL225411; 2-((2,4-dichlorophenyl)amino)-N-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide; TWQYWUXBZHPIIV-UHFFFAOYSA-N; 842166X; MLS006010287; C18H17Cl2F3N4O2; SCHEMBL3015040; DTXSID60216786; MolPort-009-019-316; HMS3656P06; BCP05306; ZINC3947932; BDBM50211843; s2778; 2455AH; AKOS032945128; DB11903; BCP9000755; CS-7768; SB19546; API0013938; GW-842,166X; NCGC00346697-05; NCGC00346697-01; KB-77649; HY-14167
Cross-matching ID
PubChem CID
10253143
ChEBI ID
CHEMBL225411
CAS Number
CAS 666260-75-9
TTD Drug ID
D0Q7NB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.96 6.47e-3 34/36 (94.44%) POLE2;PRIM1;RPA3;...
Homologous recombination 1.86 9.70e-3 35/41 (85.37%) RBBP8;RPA3;RAD51;...
Cell cycle 1.84 1.94e-2 110/124 (88.71%) CDK1;SFN;CCNE2;...
Fanconi anemia pathway 1.79 2.42e-2 36/54 (66.67%) FANCG;RPA3;RAD51;...
Pantothenate and CoA biosynthesis 1.79 2.07e-2 14/21 (66.67%) BCAT1;ALDH3A2;AASDHPPT;...
One carbon pool by folate 1.77 1.94e-2 15/20 (75%) TYMS;MTHFD1;SHMT1;...
Nitrogen metabolism 1.75 2.03e-2 16/17 (94.12%) CA2;CA3;CA12;...
Mismatch repair 1.74 1.86e-2 22/23 (95.65%) MSH2;RPA3;RPA2;...
Cysteine and methionine metabolism 1.73 2.16e-2 43/50 (86%) BCAT1;ENOPH1;MAT2B;...
Folate biosynthesis 1.71 2.52e-2 23/26 (88.46%) GGH;MOCS2;MOCOS;...
Glycine, serine and threonine metabolism 1.65 4.17e-2 31/40 (77.5%) GATM;GAMT;MAOB;...
Legionellosis 1.65 4.09e-2 51/57 (89.47%) CXCL2;CXCL8;EEF1A2;...
Alanine, aspartate and glutamate metabolism 1.65 4.23e-2 27/37 (72.97%) ASS1;ALDH5A1;GAD2;...
Sulfur metabolism 1.63 4.39e-2 9/10 (90%) PAPSS2;SELENBP1;PAPSS1;...
TGF-beta signaling pathway 1.62 4.66e-2 81/94 (86.17%) TGIF1;FST;TGIF2;...
B cell receptor signaling pathway -1.66 4.14e-2 71/81 (87.65%) RAC1;LILRA1;RASGRP3;...
Inflammatory bowel disease -1.70 2.68e-2 58/65 (89.23%) HLA-DMB;IL2RG;HLA-DRA;...
Hematopoietic cell lineage -1.72 2.36e-2 90/99 (90.91%) ITGA1;IL5;ITGA2B;...
Viral myocarditis -1.73 2.01e-2 53/60 (88.33%) CASP9;LAMA2;ABL1;...
AMPK signaling pathway -1.73 2.05e-2 106/120 (88.33%) LEP;LEPR;SCD5;...
Phosphatidylinositol signaling system -1.76 1.72e-2 82/97 (84.54%) ITPR2;PIP4K2A;PIP5K1A;...
Regulation of lipolysis in adipocytes -1.77 1.64e-2 52/55 (94.55%) LIPE;CGA;ADCY9;...
Cell adhesion molecules -1.78 1.45e-2 118/148 (79.73%) CLDN3;CDH3;NRXN3;...
Asthma -1.80 1.45e-2 25/31 (80.65%) HLA-DMB;RNASE3;HLA-DRA;...
Th17 cell differentiation -1.80 1.57e-2 95/107 (88.79%) GATA3;RELA;IRF4;...
Mitophagy -1.80 1.71e-2 56/68 (82.35%) RRAS;BCL2L13;RAB7A;...
Steroid biosynthesis -1.85 1.01e-2 19/20 (95%) DHCR7;SOAT2;DHCR24;...
Non-small cell lung cancer -1.91 4.83e-3 70/72 (97.22%) PIK3CB;RXRB;AKT1;...
Endometrial cancer -1.91 3.62e-3 56/58 (96.55%) SOS2;TP53;AKT3;...
Herpes simplex virus 1 infection -1.93 2.07e-3 165/498 (33.13%) STAT1;SRSF6;IFNAR1;...
Type I diabetes mellitus -1.95 0.00e+0 38/43 (88.37%) HLA-F;PRF1;GZMB;...
Antigen processing and presentation -1.95 0.00e+0 60/78 (76.92%) CIITA;B2M;HLA-F;...
Autoimmune thyroid disease -1.95 0.00e+0 46/53 (86.79%) TPO;HLA-F;PRF1;...
Allograft rejection -2.13 0.00e+0 32/38 (84.21%) HLA-F;PRF1;GZMB;...
Th1 and Th2 cell differentiation -2.25 0.00e+0 80/92 (86.96%) STAT1;IL13;IL5;...
Graft-versus-host disease -2.47 0.00e+0 32/42 (76.19%) HLA-F;PRF1;GZMB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H