Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMOVH1M)

• Drug Name: Oxytetracycline Drug Info
• Synonyms: Adamycin; Biostat; Dabicycline; Dalimycin; Fanterrin; Geomycin; Geotilin; Hydroxytetracycline; Imperacin; Lenocycline; Macocyn; OTC; Oksisyklin; Ossitetraciclina; Oxacycline; Oxitetraciclina; Oxitetracyclin; Oxitetracycline; Oxitetracyclinum; Oxymycin; Oxymykoin; Oxypam; Oxyterracin; Oxyterracine; Oxyterracyne; Oxytetracid; Oxytetracyclin; Oxytetracyclinum; Proteroxyna; Riomitsin; Ryomycin; Solkaciclina; Tarocyn; Tarosin; Teravit; Terrafungine; Terramitsin; Terramycin; Tetran; Unimycin; Ursocyclin; Ursocycline; Vendarcin; Biostat PA; Ossitetraciclina [DCIT]; Oxytetracycline HCl; Oxytetracycline [INN]; Oxytetracycline amphoteric; Oxytetracycline anhydrous; Oxytetracycline calcium; Terramycin im; Antibiotic TM 25; LA 200; Liquamycin LA 200; Mycoshield TMQTHC 20; Pennox 200; TM 5; Terramycin Q50; Geomycin (Streptomyces vimosus); OTC (antibiotic); Oxitetraciclina [INN-Spanish]; Oxytetracycline (anhydrous); Oxytetracycline (internal use); Oxytetracyclinum [INN-Latin]; Terramycin, Liquamycin, Oxytetracycline; (2E,4S,4aR,5S,5aR,6S,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione; (2E,4S,6S,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione; (2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione; (2Z,4S,4aR,5S,5aR,6S,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione; (4S,4aR,5S,5aR,6S,12aS)-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide; 5-Hydroxytetracycline
• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 54675779
  ChEBI ID: CHEMBL27701
  CAS Number: CAS 2058-46-0
  TTD Drug ID: D0J2NK
  VARIDT Drug ID: DR00635

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Glycine, serine and threonine metabolism	2.43	0.00e+0	31/40 (77.5%)	PSAT1;DLD;PHGDH;...
Alanine, aspartate and glutamate metabolism	2.30	0.00e+0	27/37 (72.97%)	ASS1;ASNS;ABAT;...
Arginine biosynthesis	2.22	0.00e+0	17/22 (77.27%)	ASS1;GOT1;ASL;...
Citrate cycle (TCA cycle)	2.03	0.00e+0	30/30 (100%)	PCK2;DLD;IDH3A;...
Cysteine and methionine metabolism	2.00	2.01e-3	43/50 (86%)	PSAT1;PHGDH;CBS;...
One carbon pool by folate	1.84	2.01e-2	15/20 (75%)	SHMT2;MTHFD2;GART;...
Glyoxylate and dicarboxylate metabolism	1.83	1.86e-2	23/30 (76.67%)	DLD;SHMT2;ACAT1;...
Sulfur metabolism	1.81	1.76e-2	9/10 (90%)	TST;MPST;ETHE1;...
Propanoate metabolism	1.75	3.68e-2	30/34 (88.24%)	DLD;ACAT1;ABAT;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	1.25uM - 40uM	3H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	24H	Show ▼