Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMOVJP3)

• Drug Name: xamoterol Drug Info
• Synonyms: ICI-118587
• Cross-matching ID:
  PubChem CID: 155774
  ChEBI ID: CHEMBL75753
  CAS Number: CAS 81801-12-9
  TTD Drug ID: D01OIK

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Valine, leucine and isoleucine degradation	2.13	0.00e+0	42/48 (87.5%)	HMGCS1;ACAA2;DLD;...
Phenylalanine metabolism	1.86	1.42e-2	14/17 (82.35%)	DDC;GOT1;HPD;...
PPAR signaling pathway	1.79	3.46e-2	66/74 (89.19%)	HMGCS1;ACSL1;FABP1;...
Citrate cycle (TCA cycle)	1.75	4.25e-2	30/30 (100%)	IDH2;ACO2;DLD;...
Complement and coagulation cascades	1.74	4.91e-2	76/85 (89.41%)	CFB;VWF;CLU;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	10uM	72H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼