Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMOX1CU)

Drug Name
NCX-4016 Drug Info
Synonyms
Nitroaspirin; Ncx 4016; NO-ASA; Nitric oxide-releasing aspirin; M-NO-ASA; M-NO-aspirin; [3-(nitrooxymethyl)phenyl] 2-acetyloxybenzoate; Benzoic acid, 2-(acetyloxy)-, 2-((nitrooxy)methyl)phenyl ester; Benzoic acid, 2-(acetyloxy)-, 3-((nitrooxy)methyl)phenyl ester; 2-((Nitrooxy)methyl)phenyl 2-(acetyloxy)benzoate; 2-Acetoxybenzoate-2-(1-nitroxymethyl)phenyl ester; 2-Acetoxybenzoic acid 3-(nitrooxymethyl)phenyl ester; 2-Acetoxybenzoic acid 3-nitrooxymethylphenyl ester; 3-((Nitrooxy)methyl)phenyl 2-(acetyloxy)benzoate; 3-(Nitroxymethyl)phenyl 2-acetoxybenzoate
Therapeutic ClassAnalgesics
Cross-matching ID
PubChem CID
119032
ChEBI ID
CHEMBL125482
CAS Number
CAS 175033-36-0
TTD Drug ID
D05OQX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 2.38 0.00e+0 127/171 (74.27%) DNAJB1;HSPA6;HSPA8;...
Antigen processing and presentation 2.33 0.00e+0 60/78 (76.92%) HSPA6;HSPA8;HSPA1A;...
Legionellosis 2.31 0.00e+0 51/57 (89.47%) HSPA6;HSPA8;HSPA1A;...
Other glycan degradation 2.12 0.00e+0 13/18 (72.22%) NEU1;HEXB;HEXA;...
Prion disease 1.90 1.14e-2 209/273 (76.56%) HSPA6;HSPA8;HSPA1A;...
IL-17 signaling pathway 1.86 1.27e-2 84/94 (89.36%) HSP90AA1;CXCL8;FOSL1;...
Fluid shear stress and atherosclerosis 1.78 2.85e-2 123/139 (88.49%) HMOX1;HSP90AA1;SQSTM1;...
Ferroptosis 1.74 3.80e-2 36/41 (87.8%) HMOX1;MAP1LC3B;SLC7A11;...
Rheumatoid arthritis 1.73 3.59e-2 78/93 (83.87%) CXCL8;ATP6V1G1;CXCL2;...
Steroid biosynthesis 1.73 3.23e-2 19/20 (95%) SC5D;HSD17B7;NSDHL;...
Amino sugar and nucleotide sugar metabolism 1.71 3.80e-2 38/48 (79.17%) GPI;CYB5R1;HEXB;...
Vibrio cholerae infection 1.67 4.99e-2 44/50 (88%) GNAS;ATP6V1G1;SLC12A2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H