Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMOY2AI)

Drug Name
HC-030031 Drug Info
Synonyms TRPA1 inhibitor (pain/inflammation), Hydra Biosciences/Cubist Pharmaceuticals
Cross-matching ID
PubChem CID
1150897
ChEBI ID
CHEMBL1086310
CAS Number
CAS 349085-38-7
TTD Drug ID
D0D6MC

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Type I diabetes mellitus 2.16 0.00e+0 38/43 (88.37%) CPE;HLA-DRA;GZMB;...
Antigen processing and presentation 2.05 5.17e-3 60/78 (76.92%) HSPA8;HLA-DRA;CD8A;...
Graft-versus-host disease 2.03 3.45e-3 32/42 (76.19%) HLA-DRA;GZMB;HLA-DQB1;...
Allograft rejection 2.02 2.59e-3 32/38 (84.21%) HLA-DRA;GZMB;HLA-DQB1;...
Th1 and Th2 cell differentiation 1.95 4.14e-3 80/92 (86.96%) HLA-DRA;MAPK13;IL2RB;...
Natural killer cell mediated cytotoxicity 1.93 3.45e-3 99/131 (75.57%) MICB;GZMB;KLRK1;...
Staphylococcus aureus infection 1.90 2.96e-3 72/95 (75.79%) HLA-DRA;DEFA6;DEFA5;...
Glycolysis / Gluconeogenesis 1.90 3.88e-3 56/67 (83.58%) PFKL;PGAM1;PKM;...
Central carbon metabolism in cancer 1.86 8.05e-3 67/70 (95.71%) PFKL;PGAM1;FGFR3;...
Asthma 1.78 1.45e-2 25/31 (80.65%) HLA-DRA;HLA-DQB1;FCER1G;...
Autoimmune thyroid disease 1.77 1.41e-2 46/53 (86.79%) HLA-DRA;GZMB;HLA-DQB1;...
T cell receptor signaling pathway 1.76 1.38e-2 93/104 (89.42%) ITK;CD8A;MAPK13;...
Glycine, serine and threonine metabolism 1.73 1.43e-2 31/40 (77.5%) PGAM1;GLDC;PIPOX;...
Viral protein interaction with cytokine and cytokine re... 1.66 3.92e-2 84/100 (84%) CCL5;CXCL10;IL2RB;...
Inflammatory bowel disease 1.66 3.72e-2 58/65 (89.23%) HLA-DRA;IL2RG;RORA;...
Th17 cell differentiation 1.66 3.81e-2 95/107 (88.79%) HLA-DRA;MAPK13;IL2RB;...
Intestinal immune network for IgA production 1.65 3.65e-2 38/48 (79.17%) HLA-DRA;CXCR4;HLA-DQB1;...
Chemokine signaling pathway 1.63 4.54e-2 163/192 (84.9%) CCL5;CXCL10;ITK;...
Primary immunodeficiency 1.62 4.90e-2 33/38 (86.84%) CD8A;IL2RG;IL7R;...
Fructose and mannose metabolism 1.61 4.81e-2 30/33 (90.91%) PFKL;TPI1;KHK;...
Glyoxylate and dicarboxylate metabolism 1.61 4.63e-2 23/30 (76.67%) GLDC;ACAT2;DLD;...
Ferroptosis -1.79 2.89e-2 36/41 (87.8%) CP;SLC39A8;PRNP;...
Protein digestion and absorption -1.82 3.21e-2 78/103 (75.73%) COL9A1;KCNN4;SLC7A8;...
ECM-receptor interaction -1.94 1.45e-2 80/88 (90.91%) COL9A3;ITGB5;ITGB4;...
Amoebiasis -2.07 0.00e+0 99/102 (97.06%) SERPINB9;TGFB2;MUC2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H