Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMOY9J8)

• Drug Name: (-)-norfenfluramine Drug Info
• Synonyms: l-norfenfluramine; 37577-22-3; (R)-1-(3-TRIFLUOROMETHYLPHENYL)-2-AMINOPROPANE; UNII-ODG984O60W; ODG984O60W; (2R)-1-[3-(trifluoromethyl)phenyl]propan-2-amine; Benzeneethanamine, a-methyl-3-(trifluoromethyl)-, (; (R)-Norfenfluramin; (R)-Norfenfluramine; Norfenfluramine, (R)-; GTPL217; (R)-1-(3-(trifluoromethyl)phenyl)propan-2-amine; SCHEMBL895637; CHEMBL250881; BDBM85598; CTK4H8426; MLBHFBKZUPLWBD-SSDOTTSWSA-N; CHEBI:125653; ZINC2039145; PDSP1_000697; PDSP2_000687; PDSP1_001422; AKOS030231006
• Cross-matching ID:
  PubChem CID: 12895728
  ChEBI ID: CHEMBL125653
  CAS Number: CAS 37577-22-3
  TTD Drug ID: D0H3MO

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Arginine and proline metabolism	1.96	1.49e-2	39/50 (78%)	ALDH2;CKB;CKM;...
Retinol metabolism	-1.78	4.50e-2	41/68 (60.29%)	CYP1A2;ALDH1A1;CYP26B1;...
Phagosome	-1.80	4.67e-2	118/152 (77.63%)	PIKFYVE;NCF2;CYBA;...
Staphylococcus aureus infection	-1.96	9.21e-3	72/95 (75.79%)	SELP;HLA-DPA1;HLA-DRB1;...
Steroid hormone biosynthesis	-1.97	1.23e-2	43/61 (70.49%)	CYP1A2;SRD5A1;STS;...
Systemic lupus erythematosus	-2.03	6.14e-3	45/135 (33.33%)	HLA-DOB;IFNG;C8B;...
Complement and coagulation cascades	-2.42	0.00e+0	76/85 (89.41%)	CFHR4;C8B;FGB;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Hide ▲