General Information of Drug (ID: DMP089G)

Drug Name
ZK 756326 Drug Info
Synonyms ZK-756326; ZK756326
Cross-matching ID
PubChem CID
56972201
TTD Drug ID
D03DTZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.16 0.00e+0 34/36 (94.44%) RFC5;PCNA;MCM5;...
Primary immunodeficiency 1.86 2.54e-2 33/38 (86.84%) IGLL1;PTPRC;ADA;...
Central carbon metabolism in cancer 1.85 1.70e-2 67/70 (95.71%) FGFR1;SLC2A1;SLC7A5;...
Base excision repair 1.76 2.70e-2 29/33 (87.88%) PCNA;PARP2;FEN1;...
Pyrimidine metabolism 1.74 2.80e-2 40/56 (71.43%) TYMS;DCTPP1;CANT1;...
Butanoate metabolism 1.74 2.44e-2 23/28 (82.14%) ALDH5A1;BDH2;HMGCS1;...
One carbon pool by folate 1.73 2.54e-2 15/20 (75%) TYMS;MTHFD1;ATIC;...
Ribosome biogenesis in eukaryotes 1.70 3.34e-2 52/108 (48.15%) RCL1;RBM28;RPP40;...
Legionellosis -1.62 4.41e-2 51/57 (89.47%) HSPA6;NFKBIA;RELA;...
Renal cell carcinoma -1.63 4.27e-2 68/69 (98.55%) EGLN1;MAP2K2;CDC42;...
Dilated cardiomyopathy -1.63 4.38e-2 86/96 (89.58%) MYH7;CACNG4;MYH6;...
Thyroid hormone synthesis -1.65 4.28e-2 66/75 (88%) GPX1;PRKCB;CREB1;...
Proteasome -1.65 4.28e-2 44/46 (95.65%) PSMA2;IFNG;PSMB9;...
Parathyroid hormone synthesis, secretion and action -1.66 4.00e-2 98/106 (92.45%) MMP25;PRKCB;SLC34A2;...
Collecting duct acid secretion -1.67 3.93e-2 22/27 (81.48%) ATP6V1D;ATP6V1E1;ATP6V1A;...
Non-alcoholic fatty liver disease -1.69 3.43e-2 126/155 (81.29%) SREBF1;RAC1;MAPK14;...
Sulfur metabolism -1.69 3.33e-2 9/10 (90%) PAPSS1;TST;PAPSS2;...
Epithelial cell signaling in Helicobacter pylori infect... -1.71 2.88e-2 62/70 (88.57%) ATP6V0A4;ADAM17;RAC1;...
Cortisol synthesis and secretion -1.71 2.82e-2 58/65 (89.23%) ITPR3;MC2R;CACNA1H;...
Synaptic vesicle cycle -1.72 2.97e-2 63/78 (80.77%) UNC13B;SLC17A7;ATP6V1D;...
Pathways of neurodegeneration -1.75 2.35e-2 354/475 (74.53%) GRIA1;ITPR3;SIGMAR1;...
Protein export -1.75 2.49e-2 17/23 (73.91%) SRP9;SEC62;SEC11A;...
Phagosome -1.76 2.38e-2 118/152 (77.63%) DYNC1H1;HLA-DPA1;HLA-DOB;...
Pathogenic Escherichia coli infection -1.76 2.44e-2 152/197 (77.16%) CLDN9;RELA;TMBIM6;...
Amyotrophic lateral sclerosis -1.78 2.11e-2 267/364 (73.35%) GRIA1;ITPR3;SIGMAR1;...
Diabetic cardiomyopathy -1.79 2.06e-2 162/203 (79.8%) COX8A;G6PD;INSR;...
Folate biosynthesis -1.81 2.11e-2 23/26 (88.46%) ALPL;CBR1;TH;...
Prion disease -1.82 2.18e-2 209/273 (76.56%) ITPR3;RYR1;RAC1;...
Protein processing in endoplasmic reticulum -1.85 1.97e-2 127/171 (74.27%) SEC61A1;CKAP4;BAG1;...
Salmonella infection -1.95 6.26e-3 198/249 (79.52%) EXOC7;NAIP;ARL8B;...
Thermogenesis -1.96 7.04e-3 173/232 (74.57%) MAPK14;CYC1;TSC1;...
Huntington disease -1.99 6.04e-3 233/306 (76.14%) CYC1;GPX1;KIF5C;...
Cardiac muscle contraction -2.00 7.04e-3 64/87 (73.56%) COX7A1;CACNB2;ATP2A1;...
Parkinson disease -2.05 0.00e+0 176/249 (70.68%) PRKACA;GNAI2;MFN1;...
Ribosome -2.05 0.00e+0 113/158 (71.52%) RSL24D1;MRPS12;RPS21;...
Vibrio cholerae infection -2.14 0.00e+0 44/50 (88%) ERO1A;ATP6V1F;PRKCA;...
Coronavirus disease -2.15 0.00e+0 215/232 (92.67%) IL2;IFNA8;RPL38;...
Oxidative phosphorylation -2.41 0.00e+0 93/133 (69.92%) ATP6V1F;COX7A2L;COX6A2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H