Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMP0OVQ)

Drug Name
Gestrinone Drug Info
Synonyms Dimetrose (TN)
Cross-matching ID
PubChem CID
27812
ChEBI ID
CHEMBL1868702
CAS Number
CAS 16320-04-0
TTD Drug ID
D0M5RF
INTEDE Drug ID
DR0771

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 1.92 2.06e-2 52/108 (48.15%) NVL;NOP56;HEATR1;...
Inflammatory bowel disease -1.68 1.98e-2 58/65 (89.23%) TNF;IL5;IFNGR2;...
Amino sugar and nucleotide sugar metabolism -1.69 1.96e-2 38/48 (79.17%) PMM1;FPGT;UGDH;...
Toll-like receptor signaling pathway -1.70 1.91e-2 94/104 (90.38%) TNF;RAC1;PIK3R1;...
Th1 and Th2 cell differentiation -1.71 1.75e-2 80/92 (86.96%) IL5;MAPK11;IFNGR2;...
Metabolism of xenobiotics by cytochrome P450 -1.71 1.77e-2 49/77 (63.64%) CYP2A13;ALDH3B1;CBR3;...
Asthma -1.73 1.39e-2 25/31 (80.65%) MS4A2;TNF;IL5;...
C-type lectin receptor signaling pathway -1.76 1.14e-2 93/104 (89.42%) CCL22;TNF;RELB;...
Fluid shear stress and atherosclerosis -1.77 1.13e-2 123/139 (88.49%) TNF;ACVR1;RAC1;...
Lysosome -1.79 8.47e-3 115/128 (89.84%) GGA1;ATP6V0B;IDS;...
Th17 cell differentiation -1.82 5.92e-3 95/107 (88.79%) IL6ST;MAPK11;HSP90AB1;...
Phagosome -1.83 4.97e-3 118/152 (77.63%) RAC1;ATP6V1B2;CORO1A;...
Bladder cancer -1.84 3.92e-3 40/41 (97.56%) MMP9;NRAS;THBS1;...
Cell adhesion molecules -1.86 2.07e-3 118/148 (79.73%) PTPRC;CADM1;HLA-DRA;...
Intestinal immune network for IgA production -1.87 1.46e-3 38/48 (79.17%) LTBR;IL15;IL5;...
Epithelial cell signaling in Helicobacter pylori infect... -1.89 7.77e-4 62/70 (88.57%) ATP6V0B;ATP6V1H;RAC1;...
Primary bile acid biosynthesis -1.90 8.28e-4 15/17 (88.24%) CYP7B1;SLC27A5;SCP2;...
Viral protein interaction with cytokine and cytokine re... -1.90 8.87e-4 84/100 (84%) IL20RA;CXCL2;CCL24;...
Collecting duct acid secretion -1.90 9.56e-4 22/27 (81.48%) ATP6V1A;ATP6V1G1;SLC12A7;...
Autoimmune thyroid disease -1.91 1.04e-3 46/53 (86.79%) HLA-DRA;HLA-C;HLA-F;...
Malaria -1.94 1.13e-3 44/50 (88%) CR1;LRP1;CSF3;...
Tyrosine metabolism -1.95 1.24e-3 30/36 (83.33%) AOX1;ADH1C;GSTZ1;...
Pentose phosphate pathway -1.96 1.38e-3 25/30 (83.33%) RBKS;GPI;PRPS2;...
Cytokine-cytokine receptor interaction -1.97 1.55e-3 246/295 (83.39%) CCL7;INHA;CSF1;...
Staphylococcus aureus infection -1.97 1.77e-3 72/95 (75.79%) IL10;DEFA6;KRT12;...
Osteoclast differentiation -2.02 2.07e-3 117/127 (92.13%) TNF;RAC1;RELB;...
Graft-versus-host disease -2.09 0.00e+0 32/42 (76.19%) HLA-DRA;HLA-C;HLA-F;...
Type I diabetes mellitus -2.13 0.00e+0 38/43 (88.37%) HLA-DRA;HLA-C;HLA-F;...
Hematopoietic cell lineage -2.21 0.00e+0 90/99 (90.91%) HLA-DPB1;GYPA;CD5;...
Allograft rejection -2.24 0.00e+0 32/38 (84.21%) TNF;IL5;HLA-DRA;...
Rheumatoid arthritis -2.38 0.00e+0 78/93 (83.87%) JUN;LTB;ATP6V1A;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.125uM - 3.33uM 24H