Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMP21ST)

Drug Name
BHF-177 Drug Info
Synonyms Allosteric GABA B receptor modulators, Novartis; CGP-13501; CGP-7930; CPG-37656; GS-39783
Cross-matching ID
PubChem CID
56940925
ChEBI ID
CHEMBL2346820
CAS Number
CAS 917896-43-6
TTD Drug ID
D06VMV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.79 4.50e-2 79/89 (88.76%) MAPK14;CD247;LCK;...
B cell receptor signaling pathway -1.84 3.26e-2 71/81 (87.65%) INPPL1;PIK3CA;LYN;...
Caffeine metabolism -1.86 3.56e-2 5/6 (83.33%) NAT2;XDH;NAT1;...
Steroid biosynthesis -1.95 1.78e-2 19/20 (95%) NSDHL;DHCR7;HSD17B7;...
ErbB signaling pathway -1.97 2.37e-2 79/85 (92.94%) PAK5;CRK;MAPK9;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 6H, 24H