Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMP2BFG)

Drug Name
Anacetrapib Drug Info
Synonyms MK0859; Anacetrapib (USAN); MK-0859
Cross-matching ID
PubChem CID
11556427
ChEBI ID
CHEMBL1800807
CAS Number
CAS 875446-37-0
TTD Drug ID
D07HLS
INTEDE Drug ID
DR1884

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Autoimmune thyroid disease 2.00 1.06e-2 46/53 (86.79%) HLA-DQA1;TG;HLA-F;...
Cell cycle 1.89 3.19e-2 110/124 (88.71%) CCND1;CDC25B;CCNB1;...
Herpes simplex virus 1 infection 1.88 2.13e-2 165/498 (33.13%) SRC;SRSF6;HLA-DQA1;...
Allograft rejection 1.87 2.13e-2 32/38 (84.21%) HLA-DQA1;HLA-F;HLA-B;...
NOD-like receptor signaling pathway 1.83 2.76e-2 145/181 (80.11%) GBP1;CXCL8;TNFAIP3;...
Graft-versus-host disease 1.78 3.54e-2 32/42 (76.19%) HLA-DQA1;HLA-F;HLA-B;...
Measles 1.76 3.80e-2 133/139 (95.68%) HSPA8;CCND1;TNFAIP3;...
Epstein-Barr virus infection 1.75 3.85e-2 189/202 (93.56%) NFKBIE;CCND1;TNFAIP3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H