Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMP4HR2)

• Drug Name: TG003 Drug Info
• Synonyms: Clk inhibitor; TG 003; TG-003
• Cross-matching ID:
  PubChem CID: 1893668
  ChEBI ID: CHEMBL408982
  TTD Drug ID: D06MBI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	1.96	0.00e+0	34/36 (94.44%)	POLD1;PRIM2;SSBP1;...
Spliceosome	1.91	4.04e-3	101/150 (67.33%)	HSPA8;SRSF1;LSM5;...
Mismatch repair	1.84	1.35e-2	22/23 (95.65%)	POLD1;MSH6;SSBP1;...
PPAR signaling pathway	1.83	1.21e-2	66/74 (89.19%)	CD36;SCD;SORBS1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲