Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMP54C7)

• Drug Name: Bacampicillin Drug Info
• Synonyms: Bacampicilina; Bacampicilline; Bacampicillinum; Penglobe; Bacampicillin hydrochloride; Bacampicilina [INN-Spanish]; Bacampicillin (INN); Bacampicillin [INN:BAN]; Bacampicilline [INN-French]; Bacampicillinum [INN-Latin]; Penglobe (TN); Spectrobid (TN); (2S,5R,6R)-6((R)-(2-Amino-2-phenylacetamido))-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid ester with ethyl 1-hydroxyethylcarbonate; 1'-Ethoxycarbonyloxyethyl-(6-D-alpha-aminophenylacetamido)penicillanate; 1-Ethoxycarbonyloxyethyl (2S,5R,6R)-6((R)-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptan-2-carboxylat; 1-[(ethoxycarbonyl)oxy]ethyl (2S,5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; 1-[(ethoxycarbonyl)oxy]ethyl 6beta-[(2R)-2-amino-2-phenylacetamido]-2,2-dimethylpenam-3alpha-carboxylate; 1-ethoxycarbonyloxyethyl (2S,5R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; 1-ethoxycarbonyloxyethyl (2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; 1-ethoxycarbonyloxyethyl (2S,5R,6R)-6-[[(2S)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; 6-((R)-2-Amino-2-phenylacetamido)penicillansaeure-(1-(ethoxycarbonyloxy)ethylester
• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 441397
  ChEBI ID: CHEMBL2968
  CAS Number: CAS 50972-17-3
  TTD Drug ID: D04CFW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Folate biosynthesis	2.11	0.00e+0	23/26 (88.46%)	AKR1B10;GGH;PTS;...
Metabolism of xenobiotics by cytochrome P450	2.09	0.00e+0	49/77 (63.64%)	UGT2B4;ADH1B;GSTA1;...
Retinol metabolism	2.06	0.00e+0	41/68 (60.29%)	UGT2B4;ADH1B;ADH1C;...
Drug metabolism	2.01	0.00e+0	78/151 (51.66%)	UGT2B4;ADH1B;GSTA1;...
Systemic lupus erythematosus	1.93	3.55e-3	45/135 (33.33%)	C5;C9;C7;...
Steroid hormone biosynthesis	1.82	1.48e-2	43/61 (70.49%)	AKR1C2;UGT2B4;AKR1C1;...
Complement and coagulation cascades	1.80	1.65e-2	76/85 (89.41%)	CLU;C5;CFD;...
Ascorbate and aldarate metabolism	1.76	2.66e-2	15/30 (50%)	UGT2B4;UGT2B15;UGT2B28;...
Pentose and glucuronate interconversions	1.76	2.56e-2	17/34 (50%)	AKR1B10;UGT2B4;UGT2B15;...
Bile secretion	1.66	4.79e-2	68/90 (75.56%)	ABCB1;UGT2B4;AQP1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲