Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMP75YK)

Drug Name
L-741742 Drug Info
Synonyms
L-741742; UNII-C5B89UM05U; CHEMBL444309; C5B89UM05U; L 741742; L-741,742; L741742; Cmpepi-3; Tocris-1004; Biomol-NT_000048; GTPL3302; SCHEMBL1388774; BPBio1_001096; DTXSID0043894; CHEBI:92229; ZINC602172; AC1L3203; BDBM50050476; NCGC00024933-02; NCGC00024933-01; L016523; L 741,742; BRD-K13211965-001-02-2; BRD-K13211965-003-01-0; BRD-K13211965-001-01-4; 5-(4-chlorophenyl)-4-methyl-3-(1-phenethylpiperidin-4-yl)-1,2-oxazole; 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole
Cross-matching ID
PubChem CID
133008
ChEBI ID
CHEMBL92229
CAS Number
CAS 156337-32-5
TTD Drug ID
D0WU9R

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.11 0.00e+0 19/20 (95%) MSMO1;LSS;CYP51A1;...
Ubiquinone and other terpenoid-quinone biosynthesis 1.82 4.11e-2 9/11 (81.82%) NQO1;COQ2
Citrate cycle (TCA cycle) 1.80 4.30e-2 30/30 (100%) IDH1;CS;DLD;...
Asthma 1.80 3.23e-2 25/31 (80.65%) HLA-DQA1;CCL11;HLA-DQB1;...
Endocrine and other factor-regulated calcium reabsorpti... 1.79 3.05e-2 49/53 (92.45%) PLCB1;GNAS;PRKCA;...
Steroid hormone biosynthesis -1.86 3.21e-2 43/61 (70.49%) CYP11A1;HSD17B8;CYP21A2;...
Porphyrin and chlorophyll metabolism -1.97 1.60e-2 23/43 (53.49%) UGT2A3;UGT2B15;CP;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H