Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMP7MRC)

Drug Name
Bulleyaconitine A Drug Info
Synonyms XEL-002BP; Bulleyaconitine A (transdermal matrix patch/sustained release, pain); Bulleyaconitine A (transdermal matrix patch/sustained release, pain), Xel Pharmaceuticals
Cross-matching ID
PubChem CID
24721310
TTD Drug ID
D04ATY

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 1.98 1.51e-2 93/133 (69.92%) COX6B1;NDUFB1;ATP5MF;...
Nitrogen metabolism -1.64 4.98e-2 16/17 (94.12%) CA7;CA3;CA6;...
Nicotinate and nicotinamide metabolism -1.66 4.13e-2 25/35 (71.43%) NT5M;NMRK1;AOX1;...
Bile secretion -1.67 4.15e-2 68/90 (75.56%) UGT2B28;SLCO1A2;PRKACA;...
TNF signaling pathway -1.69 3.20e-2 103/112 (91.96%) MAP2K3;CEBPB;CREB3;...
Glyoxylate and dicarboxylate metabolism -1.69 3.45e-2 23/30 (76.67%) SHMT1;AGXT;ACO2;...
Porphyrin and chlorophyll metabolism -1.69 3.63e-2 23/43 (53.49%) UGT2B15;BLVRB;ALAS2;...
Cardiac muscle contraction -1.74 2.26e-2 64/87 (73.56%) CACNG2;CACNA2D2;TRDN;...
Starch and sucrose metabolism -1.76 1.74e-2 25/36 (69.44%) GCK;GYS1;PYGL;...
Adrenergic signaling in cardiomyocytes -1.80 8.30e-3 130/150 (86.67%) CREM;ADCY6;SCN1B;...
Protein processing in endoplasmic reticulum -1.81 6.23e-3 127/171 (74.27%) PREB;HSPA5;SEC61B;...
Longevity regulating pathway -1.84 5.34e-3 90/151 (59.6%) CREB3;PIK3R2;CREB1;...
Hypertrophic cardiomyopathy -1.85 4.15e-3 81/90 (90%) CACNG2;CACNA2D2;TGFB1;...
Dilated cardiomyopathy -1.90 2.49e-3 86/96 (89.58%) CACNG2;CACNA2D2;ADCY1;...
Glycine, serine and threonine metabolism -2.03 3.11e-3 31/40 (77.5%) SHMT1;SARDH;GNMT;...
Legionellosis -2.04 4.15e-3 51/57 (89.47%) C3;CD14;PYCARD;...
Ferroptosis -2.09 0.00e+0 36/41 (87.8%) MAP1LC3B;STEAP3;TF;...
Mineral absorption -2.17 0.00e+0 48/60 (80%) MT1HL1;ATP1A2;MT1H;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H