Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMP8HEL)

• Drug Name: Mitiglinide Drug Info
• Synonyms: Mitiglinide calcium; Mitiglinide calcium hydrate; KAD 1229; S21403; Glufast (TN); Kad-1229; Calcium 2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate dihydrate; Calcium (2S)-4-[(3aS,7aR)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-2-benzyl-4-oxobutanoate; (2S)-4-[(3aR,7aS)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-2-benzyl-4-oxobutanoic acid; 2-Benzyl-3-(hexahydro-2-isoindolinylcarbonyl)propionate
• Therapeutic Class: Hypoglycemic Agents
• Cross-matching ID:
  PubChem CID: 121891
  ChEBI ID: CHEMBL135349
  CAS Number: CAS 145375-43-5
  TTD Drug ID: D0P2YU
  INTEDE Drug ID: DR1101

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Alcoholism	2.07	0.00e+0	86/186 (46.24%)	CREB1;SHC1;GNAI1;...
IL-17 signaling pathway	2.06	0.00e+0	84/94 (89.36%)	CXCL8;CXCL5;S100A7;...
Asthma	1.93	1.23e-2	25/31 (80.65%)	CD40;HLA-DRA;HLA-DRB1;...
Cocaine addiction	1.93	9.21e-3	42/49 (85.71%)	CREB1;GNAI1;FOSB;...
NF-kappa B signaling pathway	1.91	7.37e-3	90/104 (86.54%)	CXCL8;CD40;BCL2A1;...
Allograft rejection	1.87	8.18e-3	32/38 (84.21%)	CD40;HLA-DRA;HLA-DRB1;...
Renin secretion	1.87	7.02e-3	61/69 (88.41%)	CREB1;ITPR1;GNAI1;...
Graft-versus-host disease	1.84	1.38e-2	32/42 (76.19%)	HLA-DRA;HLA-DRB1;IL1B;...
Type I diabetes mellitus	1.83	1.50e-2	38/43 (88.37%)	HLA-DRA;HLA-DRB1;IL1B;...
Amphetamine addiction	1.82	1.47e-2	57/69 (82.61%)	CREB1;FOSB;MAOA;...
TNF signaling pathway	1.74	3.01e-2	103/112 (91.96%)	CXCL5;CREB1;CXCL6;...
Rheumatoid arthritis	1.73	3.07e-2	78/93 (83.87%)	CXCL8;CXCL5;CXCL6;...
Pertussis	1.71	3.78e-2	64/76 (84.21%)	CXCL8;CXCL5;CXCL6;...
Mismatch repair	1.66	4.84e-2	22/23 (95.65%)	SSBP1;RFC5;EXO1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼