Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMP8TKA)

Drug Name
CY-208243 Drug Info
Synonyms
Indolophenanthridine; CY 208-243; 100999-26-6; CY-208-243; 4,6,6a,7,8,12b-Hexahydro-7-methylindolo(4,3-ab)-phenanthridine; Indolo(4,3-ab)phenanthridine, 4,6,6a,7,8,12b-hexahydro-7-methyl-, trans-(-)-; (6aR,12bR)-7-methyl-4,6,6a,7,8,12b-hexahydroindolo[4,3-ab]phenanthridine; Tocris-1249; AC1L1ODE; Biomol-NT_000032; AC1Q1IN1; CHEMBL313737; BPBio1_001225; SCHEMBL9364562; DTXSID9042598; CHEBI:93399; MolPort-003-983-825; HMS3267H13; ZINC26501186; AKOS024456489; API0009347; NCGC00025078-01; NCGC00025078-02; LS-183405
Cross-matching ID
PubChem CID
58144
ChEBI ID
CHEMBL93399
CAS Number
CAS 100999-26-6
TTD Drug ID
D0BQ8M

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Metabolism of xenobiotics by cytochrome P450 2.33 0.00e+0 49/77 (63.64%) AKR1C1;GSTM3;GSTT1;...
Glutathione metabolism 2.31 0.00e+0 43/57 (75.44%) GPX2;CHAC1;GSTM3;...
Steroid hormone biosynthesis 2.17 2.75e-3 43/61 (70.49%) AKR1C3;AKR1C2;AKR1C1;...
Oxidative phosphorylation 1.85 3.09e-2 93/133 (69.92%) SDHD;ATP6V1D;NDUFB8;...
Retinol metabolism 1.84 2.64e-2 41/68 (60.29%) ALDH1A3;ALDH1A1;CYP26B1;...
Pentose and glucuronate interconversions 1.83 2.47e-2 17/34 (50%) AKR1B10;UGDH;SORD;...
Folate biosynthesis 1.81 2.47e-2 23/26 (88.46%) AKR1C3;AKR1B10;PTS;...
Fluid shear stress and atherosclerosis 1.80 2.68e-2 123/139 (88.49%) HMOX1;GSTM3;GSTT1;...
Synthesis and degradation of ketone bodies 1.75 3.57e-2 9/10 (90%) BDH2;ACAT2;ACAT1
Alanine, aspartate and glutamate metabolism 1.75 3.22e-2 27/37 (72.97%) ABAT;GOT1;GLS;...
beta-Alanine metabolism 1.74 3.45e-2 25/30 (83.33%) ABAT;DPYD;ALDH3A1;...
Arachidonic acid metabolism 1.72 3.85e-2 48/61 (78.69%) AKR1C3;GPX2;GPX7;...
Sphingolipid metabolism 1.71 3.55e-2 32/49 (65.31%) KDSR;PLPP3;NEU1;...
Butanoate metabolism 1.71 3.36e-2 23/28 (82.14%) ABAT;BDH2;ACAT2;...
Epithelial cell signaling in Helicobacter pylori infect... 1.68 4.51e-2 62/70 (88.57%) CXCL8;SRC;ATP6V1D;...
Ribosome biogenesis in eukaryotes -1.90 3.25e-2 52/108 (48.15%) CSNK2A2;CSNK2A1;POP4;...
Staphylococcus aureus infection -1.96 1.22e-2 72/95 (75.79%) C3AR1;FPR3;FCGR2A;...
Asthma -1.97 1.22e-2 25/31 (80.65%) IL4;IL3;HLA-DRB1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H