Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPA8WO)

Drug Name
NU1025 Drug Info
Cross-matching ID
PubChem CID
135398517
ChEBI ID
CHEMBL123904
CAS Number
CAS 90417-38-2
TTD Drug ID
D0O3FX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Spliceosome 2.63 0.00e+0 101/150 (67.33%) HSPA8;HSPA1A;PPIH;...
Fanconi anemia pathway 2.32 0.00e+0 36/54 (66.67%) BRCA1;RMI1;FANCA;...
Oocyte meiosis 2.26 0.00e+0 90/129 (69.77%) CDC20;PLK1;AURKA;...
RNA transport 2.25 0.00e+0 128/186 (68.82%) NUP93;EIF5B;TACC3;...
Cell cycle 2.20 0.00e+0 110/124 (88.71%) CDC20;PLK1;CDC25A;...
DNA replication 2.19 0.00e+0 34/36 (94.44%) POLE2;PRIM1;PRIM2;...
Ribosome 1.99 9.83e-4 113/158 (71.52%) RPS4Y1;RPS26;RPL10;...
Mismatch repair 1.96 8.60e-4 22/23 (95.65%) EXO1;MSH6;RPA3;...
Progesterone-mediated oocyte maturation 1.95 7.65e-4 75/100 (75%) PLK1;AURKA;CDC25A;...
Homologous recombination 1.79 1.10e-2 35/41 (85.37%) BRCA1;RAD54B;TOPBP1;...
Ribosome biogenesis in eukaryotes 1.77 1.06e-2 52/108 (48.15%) NMD3;RPP30;NOP56;...
Retinol metabolism 1.69 2.47e-2 41/68 (60.29%) UGT2B28;UGT2B4;CYP3A7;...
Terpenoid backbone biosynthesis -1.65 3.11e-2 18/22 (81.82%) FDPS;DHDDS;IDI1;...
Graft-versus-host disease -1.68 2.77e-2 32/42 (76.19%) IL2;HLA-B;FAS;...
Osteoclast differentiation -1.69 2.55e-2 117/127 (92.13%) PPP3CC;TGFB2;CYLD;...
Cell adhesion molecules -1.69 2.60e-2 118/148 (79.73%) HLA-A;CTLA4;HLA-E;...
Autophagy -1.69 2.70e-2 113/169 (66.86%) TBK1;RPS6KB2;ATG2A;...
Phagosome -1.70 2.46e-2 118/152 (77.63%) CD209;SEC61G;RAB5B;...
Apoptosis -1.73 1.83e-2 126/168 (75%) NTRK1;TRADD;PIDD1;...
Glycerophospholipid metabolism -1.73 1.91e-2 71/98 (72.45%) DGKQ;LPCAT3;CDS2;...
Glutathione metabolism -1.74 1.94e-2 43/57 (75.44%) GSTA4;GGT1;MGST3;...
Sphingolipid metabolism -1.75 1.61e-2 32/49 (65.31%) CERK;B4GALT6;GAL3ST1;...
Arginine and proline metabolism -1.76 1.50e-2 39/50 (78%) AOC1;P4HA1;ALDH4A1;...
Mitophagy -1.78 1.19e-2 56/68 (82.35%) TBK1;TBC1D17;TFE3;...
Amino sugar and nucleotide sugar metabolism -1.78 1.25e-2 38/48 (79.17%) UAP1;GMPPA;AMDHD2;...
Glycerolipid metabolism -1.78 1.33e-2 44/61 (72.13%) PNPLA2;LPL;AKR1B10;...
Pyruvate metabolism -1.78 1.41e-2 41/47 (87.23%) PKM;DLD;MDH1;...
NF-kappa B signaling pathway -1.81 1.42e-2 90/104 (86.54%) CYLD;TRADD;PIDD1;...
Ferroptosis -1.84 1.07e-2 36/41 (87.8%) SLC11A2;GPX4;FTL;...
Intestinal immune network for IgA production -1.84 1.16e-2 38/48 (79.17%) ICOSLG;IL15;TNFRSF13B;...
Steroid biosynthesis -1.85 1.25e-2 19/20 (95%) NSDHL;DHCR7;CYP51A1;...
Glycolysis / Gluconeogenesis -1.85 1.37e-2 56/67 (83.58%) ALDH3B1;BPGM;GPI;...
Ether lipid metabolism -1.86 1.50e-2 32/49 (65.31%) PLPP2;ENPP2;PLD3;...
Central carbon metabolism in cancer -1.89 1.25e-2 67/70 (95.71%) HIF1A;NTRK1;SLC2A1;...
TNF signaling pathway -1.92 9.40e-3 103/112 (91.96%) MMP14;MAP2K4;TRADD;...
Staphylococcus aureus infection -1.93 1.07e-2 72/95 (75.79%) C3AR1;ICAM1;KRT33A;...
Hematopoietic cell lineage -1.99 6.26e-3 90/99 (90.91%) CD38;CSF2RA;IL7;...
Other glycan degradation -2.00 7.52e-3 13/18 (72.22%) FUCA1;HEXB;HEXA;...
Rheumatoid arthritis -2.15 0.00e+0 78/93 (83.87%) IL18;ATP6V1F;TCIRG1;...
Cytokine-cytokine receptor interaction -2.19 0.00e+0 246/295 (83.39%) GDF11;ACKR4;IL23A;...
Viral protein interaction with cytokine and cytokine re... -2.26 0.00e+0 84/100 (84%) ACKR4;CCL17;CX3CL1;...
Lysosome -2.29 0.00e+0 115/128 (89.84%) AP1B1;GM2A;TCIRG1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.0005uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.0005uM - 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 10uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H