Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPAJ41)

Drug Name
BIIB-021 Drug Info
Synonyms
CNF-2024; CNF-3647; EC-129; EC-137; EC-138; EC-141; EC-144; EC-146; EC-147; EC-151; EC-78; EC-89; EC-145, Conforma; EC-82, Conforma; Hsp90 inhibitor (cancer), Biogen Idec; Synthetic Hsp90 inhibitors (cancer), Conforma; Hsp90 inhibitors (synthetic, cancer), Conforma
Cross-matching ID
PubChem CID
16736529
ChEBI ID
CHEMBL467399
CAS Number
CAS 848695-25-0
TTD Drug ID
D05HWN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 1.88 7.21e-3 127/171 (74.27%) HSPA1A;HSPA8;HSPH1;...
TNF signaling pathway -1.67 4.64e-2 103/112 (91.96%) CREB3;CXCL6;BIRC2;...
Nucleotide excision repair -1.68 4.35e-2 40/47 (85.11%) ERCC1;ERCC2;RAD23A;...
NF-kappa B signaling pathway -1.70 3.63e-2 90/104 (86.54%) GADD45B;GADD45A;LCK;...
Kaposi sarcoma-associated herpesvirus infection -1.74 3.01e-2 172/193 (89.12%) MICA;GNG11;HLA-C;...
Graft-versus-host disease -1.76 2.71e-2 32/42 (76.19%) HLA-C;IL6;HLA-F;...
Leishmaniasis -1.80 1.87e-2 67/77 (87.01%) ITGA4;FCGR2C;CYBA;...
Asthma -1.83 1.24e-2 25/31 (80.65%) HLA-DQB1;HLA-DPB1;RNASE3;...
Rheumatoid arthritis -1.86 9.33e-3 78/93 (83.87%) CXCL5;HLA-DQB1;ATP6V0A2;...
Pyrimidine metabolism -1.87 8.88e-3 40/56 (71.43%) DTYMK;UCK2;DCK;...
IL-17 signaling pathway -1.90 8.29e-3 84/94 (89.36%) NFKBIA;MMP3;MAPK13;...
Base excision repair -1.92 7.46e-3 29/33 (87.88%) LIG1;POLD2;POLD1;...
Homologous recombination -1.93 6.22e-3 35/41 (85.37%) RAD51D;RAD54L;BARD1;...
Mismatch repair -2.00 0.00e+0 22/23 (95.65%) LIG1;POLD2;RPA3;...
Fanconi anemia pathway -2.23 0.00e+0 36/54 (66.67%) ERCC1;FANCE;POLI;...
DNA replication -2.63 0.00e+0 34/36 (94.44%) LIG1;POLD2;RPA3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 2.22uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H