Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPAWBN)

Drug Name
GSK525762 Drug Info
Synonyms GSK-525762
Cross-matching ID
PubChem CID
46943432
ChEBI ID
CHEMBL1232461
CAS Number
CAS 1260907-17-2
TTD Drug ID
D07OFM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mineral absorption -1.60 4.59e-2 48/60 (80%) CYBRD1;SLC26A3;ATP1A1;...
Allograft rejection -1.61 4.48e-2 32/38 (84.21%) HLA-DRB1;HLA-DPA1;CD86;...
Transcriptional misregulation in cancer -1.61 4.67e-2 158/192 (82.29%) HOXA10;ITGAM;CDKN1A;...
Herpes simplex virus 1 infection -1.62 4.51e-2 165/498 (33.13%) IFNGR1;HLA-DQB1;TICAM1;...
Antigen processing and presentation -1.62 4.47e-2 60/78 (76.92%) HLA-DQB1;B2M;TAP2;...
Inflammatory bowel disease -1.64 3.34e-2 58/65 (89.23%) IL2;TBX21;IL4R;...
Asthma -1.65 3.23e-2 25/31 (80.65%) IL3;MS4A2;HLA-DQB1;...
Retinol metabolism -1.66 2.97e-2 41/68 (60.29%) UGT2B15;DHRS9;CYP26A1;...
NF-kappa B signaling pathway -1.68 2.53e-2 90/104 (86.54%) CSNK2A2;CD14;CSNK2A1;...
IL-17 signaling pathway -1.70 2.30e-2 84/94 (89.36%) CCL17;PTGS2;CCL11;...
Synthesis and degradation of ketone bodies -1.70 2.39e-2 9/10 (90%) ACAT2;BDH1;OXCT1;...
Hematopoietic cell lineage -1.70 2.55e-2 90/99 (90.91%) IL7;CD14;CD1E;...
Graft-versus-host disease -1.71 2.47e-2 32/42 (76.19%) IL1B;HLA-DRB1;IL1A;...
Type I diabetes mellitus -1.73 2.17e-2 38/43 (88.37%) IL1B;HLA-DRB1;IL1A;...
PPAR signaling pathway -1.75 1.52e-2 66/74 (89.19%) SCP2;ME3;ACSL1;...
TNF signaling pathway -1.75 1.66e-2 103/112 (91.96%) MAPK11;FADD;CSF1;...
Intestinal immune network for IgA production -1.79 1.18e-2 38/48 (79.17%) CD80;IL2;HLA-DQB1;...
Primary immunodeficiency -1.79 1.21e-2 33/38 (86.84%) RFXAP;TNFRSF13B;CD8B;...
Malaria -1.79 1.37e-2 44/50 (88%) IL18;THBS3;THBS2;...
Complement and coagulation cascades -1.85 9.10e-3 76/85 (89.41%) CD55;PROS1;C5AR1;...
Pertussis -1.87 7.59e-3 64/76 (84.21%) C2;C3;ITGB2;...
Rheumatoid arthritis -1.99 0.00e+0 78/93 (83.87%) CTLA4;CCL5;ACP5;...
Systemic lupus erythematosus -2.05 0.00e+0 45/135 (33.33%) C2;C3;FCGR2A;...
Viral protein interaction with cytokine and cytokine re... -2.20 0.00e+0 84/100 (84%) IL20RA;CSF1;CCL23;...
Cytokine-cytokine receptor interaction -2.21 0.00e+0 246/295 (83.39%) INHBE;IL17RA;IL2;...
Staphylococcus aureus infection -2.31 0.00e+0 72/95 (75.79%) DEFB4A;KRT15;C5AR1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 24H
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 BRD4 (-) 1 CVCL_SF59 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 24H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 6H, 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H