Details of the Drug Pharmacogenomic Perturbation Atlas

Cabazitaxel Drug Info

Jevtana; Taxoid XRP6258; Jevtana (TN)

Cross-matching ID

PubChem CID

9854073

ChEBI ID

CHEMBL63584

CAS Number

CAS 183133-96-2

TTD Drug ID

D02HSB

INTEDE Drug ID

DR0252

ACDINA Drug ID

D00902

General Information of Drug (ID: DMPAZHC)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Ascorbate and aldarate metabolism	-1.63	4.58e-2	15/30 (50%)	UGDH;UGT2B4;ALDH3A2;...
Histidine metabolism	-1.63	4.77e-2	16/22 (72.73%)	AOC1;ALDH3A2;ALDH9A1;...
Sulfur metabolism	-1.68	2.65e-2	9/10 (90%)	SELENBP1;TST;SUOX;...
Homologous recombination	-1.72	1.67e-2	35/41 (85.37%)	TOP3B;RPA2;SEM1;...
Glutathione metabolism	-1.73	1.66e-2	43/57 (75.44%)	GSTA4;GPX2;GSTM3;...
Fatty acid degradation	-1.74	1.65e-2	40/43 (93.02%)	ACAA2;ACAT1;CPT1A;...
Pentose and glucuronate interconversions	-1.78	1.11e-2	17/34 (50%)	AKR1B1;UGT2A3;UGT2B15;...
Drug metabolism	-1.78	1.13e-2	78/151 (51.66%)	DUT;ADH5;MAOB;...
Protein processing in endoplasmic reticulum	-1.80	1.07e-2	127/171 (74.27%)	RNF5;VCP;DAD1;...
Glycolysis / Gluconeogenesis	-1.80	1.17e-2	56/67 (83.58%)	PFKL;ADH6;MINPP1;...
Fanconi anemia pathway	-1.81	1.28e-2	36/54 (66.67%)	TOP3B;RPA2;BRIP1;...
Cell cycle	-1.83	8.14e-3	110/124 (88.71%)	ORC6;STAG1;CCND2;...
One carbon pool by folate	-1.84	8.02e-3	15/20 (75%)	MTHFS;MTHFD1;SHMT2;...
Mismatch repair	-1.86	9.16e-3	22/23 (95.65%)	POLD2;RFC3;POLD1;...
Lysine degradation	-1.88	1.07e-2	51/63 (80.95%)	EHHADH;EHMT2;COLGALT1;...
Base excision repair	-1.91	7.33e-3	29/33 (87.88%)	LIG1;HMGB1;POLE;...
Metabolism of xenobiotics by cytochrome P450	-1.97	0.00e+0	49/77 (63.64%)	GSTA3;CYP3A4;ADH5;...
Glycine, serine and threonine metabolism	-2.01	0.00e+0	31/40 (77.5%)	GAMT;DLD;CTH;...
Glyoxylate and dicarboxylate metabolism	-2.15	0.00e+0	23/30 (76.67%)	PCCB;CS;CAT;...
DNA replication	-2.50	0.00e+0	34/36 (94.44%)	POLD2;RFC3;PRIM2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 10uM	24H