Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPBNYM)

Drug Name
(5-hydroxy-1H-indol-2-yl)(1H-indol-2-yl)methanone Drug Info
Synonyms
CHEMBL7735; PDGF Receptor Tyrosine Kinase Inhibitor I; D-64406; (5-Hydroxy-1H-2-indolyl)(1H-2-indolyl)-methanone; 249762-62-7; AC1NS9CN; BDBM6581; SCHEMBL4456469; CHEBI:92486; ZINC24261; CTK0J4476; DTXSID20416205; Bis(1H-2-indolyl)methanone 39; IN1158; HSCI1_000198; NCGC00185731-01; 5-Hydroxy-[2,2'-carbonylbis(1H-indole)]; 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-ol; BRD-K27665173-001-01-3; (5-hydroxy-1H-indol-2-yl)-(1H-indol-2-yl)methanone; Methanone, (5-hydroxy-1H-indol-2-yl)-1H-indol-2-yl-
Cross-matching ID
PubChem CID
5330535
ChEBI ID
CHEMBL7735
CAS Number
CAS 249762-62-7
TTD Drug ID
D0XS9E

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 2.27 0.00e+0 127/171 (74.27%) HERPUD1;ATF4;P4HB;...
Nitrogen metabolism 1.98 0.00e+0 16/17 (94.12%) CA2;CA3;CA4;...
Allograft rejection 1.96 3.49e-3 32/38 (84.21%) HLA-B;HLA-C;HLA-F;...
Ferroptosis 1.91 5.23e-3 36/41 (87.8%) HMOX1;SLC7A11;SLC3A2;...
Sulfur metabolism 1.91 4.18e-3 9/10 (90%) PAPSS1;ETHE1;SELENBP1;...
Graft-versus-host disease 1.90 5.23e-3 32/42 (76.19%) HLA-B;HLA-C;HLA-F;...
Autoimmune thyroid disease 1.83 1.94e-2 46/53 (86.79%) HLA-B;HLA-C;HLA-F;...
Viral myocarditis 1.82 1.83e-2 53/60 (88.33%) HLA-B;ACTB;HLA-C;...
Mitophagy 1.80 1.86e-2 56/68 (82.35%) ATF4;SRC;CALCOCO2;...
Glycine, serine and threonine metabolism 1.79 1.99e-2 31/40 (77.5%) PSAT1;CBS;CTH;...
Antigen processing and presentation 1.74 2.28e-2 60/78 (76.92%) HLA-B;HLA-C;HLA-F;...
Terpenoid backbone biosynthesis -1.84 3.19e-2 18/22 (81.82%) HMGCR;FDPS;ACAT2;...
ECM-receptor interaction -1.92 2.39e-2 80/88 (90.91%) ITGA2;ITGAV;ITGA1;...
Steroid biosynthesis -2.36 0.00e+0 19/20 (95%) LSS;DHCR24;HSD17B7;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H