Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPD41Q)

• Drug Name: prunetin Drug Info
• Synonyms: 4',5-dihydroxy-7-methoxyisoflavone
• Cross-matching ID:
  PubChem CID: 5281804
  ChEBI ID: CHEMBL491174
  CAS Number: CAS 552-59-0
  TTD Drug ID: D0A9RM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Antigen processing and presentation	1.91	3.66e-2	60/78 (76.92%)	HSPA8;HSPA1A;CANX;...
Protein processing in endoplasmic reticulum	1.91	2.44e-2	127/171 (74.27%)	HSPA8;HSPH1;HSPA1A;...
Various types of N-glycan biosynthesis	1.85	4.47e-2	26/39 (66.67%)	ALG3;MAN1C1;MAN1A1;...
Ribosome	-1.80	3.54e-2	113/158 (71.52%)	RPS3A;MRPS12;RPL34;...
Mineral absorption	-1.98	8.18e-3	48/60 (80%)	VDR;SLC30A1;SLC11A2;...
Oxidative phosphorylation	-2.04	0.00e+0	93/133 (69.92%)	NDUFA1;ATP5F1C;ATP6V1B1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Hide ▲

Lung

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼