Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPDYFR)

Drug Name
Cefazolin Drug Info
Synonyms
CEZ; Cefamezin; Cefamezine; Cefazolina; Cefazoline; Cefazolinum; Cephamezine; Cephazolidin; Cephazolin; Cephazoline; Elzogram; Cephazolin Sodium; Ancef (TN); Cefacidal (TN); Cefamezin (TN); Cefazolin (USP); Cefazolin [USAN:INN]; Cefazolin(usp); Cefazolina [INN-Spanish]; Cefazoline [INN-French]; Cefazolinum [INN-Latin]; Cefrina (TN); Elzogram (TN); Faxilen (TN); Gramaxin (TN); Kefazol (TN); Kefol (TN); Kefzol (TN); Kefzolan (TN); Kezolin (TN); Novaporin (TN); Zolicef (TN); (6R, 7R)-3-[[(5-Methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[1H-tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-3-(((5-Methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid; (6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R-trans)-3-(((5-Methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(((1H-tetrazol-1-yl)acetyl)-amino)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid; 3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-7beta-[(1H-tetrazol-1-ylacetyl)amino]-3,4-didehydrocepham-4-carboxylic acid; 7-(1-(1H-)-Tetrazolylacetamido)-3-(2-(5-methyl-1,3,4-thiadiazolyl)thiomethyl)delta3-cephem-4-carboxylic acid
Therapeutic ClassAntibiotics
Cross-matching ID
PubChem CID
33255
ChEBI ID
CHEMBL1435
CAS Number
CAS 25953-19-9
TTD Drug ID
D09KDN
VARIDT Drug ID
DR00577
INTEDE Drug ID
DR2503

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Riboflavin metabolism -1.69 4.86e-2 7/8 (87.5%) RFK;BLVRB;ACP5;...
Glycerolipid metabolism -1.70 4.89e-2 44/61 (72.13%) AGPAT1;PLPP1;DGKB;...
Pyruvate metabolism -1.70 4.82e-2 41/47 (87.23%) HAGH;PCK2;ADH7;...
beta-Alanine metabolism -1.73 4.02e-2 25/30 (83.33%) DPYD;ALDH3B1;SMOX;...
FoxO signaling pathway -1.74 3.97e-2 118/131 (90.08%) PRMT1;PRKAG2;MDM2;...
Tyrosine metabolism -1.74 4.28e-2 30/36 (83.33%) ADH7;HPD;ADH1A;...
Primary immunodeficiency -1.77 3.26e-2 33/38 (86.84%) IGLL1;ZAP70;TAP1;...
Mitophagy -1.78 3.73e-2 56/68 (82.35%) PRKN;RRAS;BECN1;...
Bladder cancer -1.80 3.97e-2 40/41 (97.56%) TP53;HBEGF;DAPK1;...
Metabolism of xenobiotics by cytochrome P450 -1.86 1.59e-2 49/77 (63.64%) ADH7;UGT2B4;SULT2A1;...
Folate biosynthesis -1.88 1.70e-2 23/26 (88.46%) GCH1;AKR1B1;MOCOS;...
Steroid hormone biosynthesis -1.88 2.27e-2 43/61 (70.49%) CYP7A1;UGT2B4;CYP11A1;...
PPAR signaling pathway -1.92 1.70e-2 66/74 (89.19%) RXRG;FABP7;ACSL5;...
Retinol metabolism -2.21 0.00e+0 41/68 (60.29%) ADH7;UGT2B4;CYP2A6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H