Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPF9ZM)

Drug Name
Obatoclax Drug Info
Synonyms CHEMBL408194; UNII-QN4128B52A; QN4128B52A; SCHEMBL631676; SCHEMBL16340850; BDBM50376902; ZINC136873052; DB12191; NCGC00387855-01; BRD-K15600710-066-01-7
Cross-matching ID
PubChem CID
11404337
CAS Number
CAS 803712-67-6
TTD Drug ID
D02OZK

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Terpenoid backbone biosynthesis 2.30 0.00e+0 18/22 (81.82%) HMGCS1;ACAT2;IDI1;...
Steroid biosynthesis 2.28 0.00e+0 19/20 (95%) MSMO1;SQLE;DHCR7;...
Amino sugar and nucleotide sugar metabolism 2.18 0.00e+0 38/48 (79.17%) HK2;GFPT1;GNPDA1;...
PPAR signaling pathway 2.11 0.00e+0 66/74 (89.19%) SCD;HMGCS1;FADS2;...
Various types of N-glycan biosynthesis 2.10 0.00e+0 26/39 (66.67%) MAN2A1;DAD1;HEXB;...
Protein processing in endoplasmic reticulum 2.10 0.00e+0 127/171 (74.27%) HERPUD1;ERO1A;SEC24D;...
Lysosome 2.07 0.00e+0 115/128 (89.84%) NPC1;NPC2;CTSB;...
Protein export 2.02 1.37e-3 17/23 (73.91%) SEC61G;SEC61A1;SPCS3;...
Vibrio cholerae infection 2.02 1.22e-3 44/50 (88%) KDELR3;ERO1A;KDELR2;...
HIF-1 signaling pathway 1.99 2.19e-3 105/109 (96.33%) ALDOC;ENO2;VEGFA;...
Glycolysis / Gluconeogenesis 1.99 1.99e-3 56/67 (83.58%) ALDOC;ENO2;HK2;...
Ferroptosis 1.96 2.74e-3 36/41 (87.8%) SLC7A11;ACSL3;SLC39A14;...
Cholesterol metabolism 1.92 5.06e-3 44/50 (88%) LDLR;NPC1;LIPG;...
Mineral absorption 1.92 4.70e-3 48/60 (80%) STEAP1;FTH1;HMOX1;...
Biosynthesis of unsaturated fatty acids 1.88 8.04e-3 21/27 (77.78%) SCD;FADS1;FADS2;...
AMPK signaling pathway 1.88 7.53e-3 106/120 (88.33%) SCD;HMGCR;FASN;...
Fructose and mannose metabolism 1.86 8.38e-3 30/33 (90.91%) ALDOC;HK2;ALDOA;...
TNF signaling pathway 1.84 8.52e-3 103/112 (91.96%) CCL20;PTGS2;ATF4;...
Phagosome 1.83 1.10e-2 118/152 (77.63%) ITGB5;COMP;CANX;...
Fatty acid biosynthesis 1.82 1.15e-2 16/18 (88.89%) FASN;ACSL3;ACACA;...
N-Glycan biosynthesis 1.81 1.10e-2 38/50 (76%) MAN2A1;DAD1;STT3A;...
Synthesis and degradation of ketone bodies 1.81 1.10e-2 9/10 (90%) HMGCS1;ACAT2;BDH1;...
IL-17 signaling pathway 1.80 1.24e-2 84/94 (89.36%) CCL20;PTGS2;CXCL8;...
Insulin resistance 1.79 1.28e-2 96/108 (88.89%) TRIB3;GFPT1;PCK2;...
Epithelial cell signaling in Helicobacter pylori infect... 1.79 1.23e-2 62/70 (88.57%) CXCL8;CXCL3;CXCL2;...
Adipocytokine signaling pathway 1.76 1.90e-2 64/69 (92.75%) ACSL3;PCK2;IRS2;...
Galactose metabolism 1.76 1.87e-2 26/31 (83.87%) HK2;GALE;PGM1;...
Rheumatoid arthritis 1.74 2.04e-2 78/93 (83.87%) VEGFA;CCL20;CXCL8;...
Glycosphingolipid biosynthesis 1.73 2.27e-2 37/57 (64.91%) SLC33A1;HEXB;ST3GAL1;...
Other glycan degradation 1.73 2.37e-2 13/18 (72.22%) NEU1;HEXB;AGA;...
ABC transporters -1.62 4.34e-2 37/45 (82.22%) ABCG1;ABCA3;ABCC5;...
Fanconi anemia pathway -1.66 3.48e-2 36/54 (66.67%) RPA3;FANCA;RAD51;...
Staphylococcus aureus infection -1.66 3.72e-2 72/95 (75.79%) C5;HLA-DQB1;SELPLG;...
RNA polymerase -1.70 2.37e-2 23/31 (74.19%) POLR2K;POLR3K;POLR2J;...
Systemic lupus erythematosus -1.81 6.37e-3 45/135 (33.33%) C6;SNRPB;SNRPD1;...
mRNA surveillance pathway -1.88 3.07e-3 71/98 (72.45%) CPSF4;DDX19A;PABPC3;...
Cell cycle -1.98 0.00e+0 110/124 (88.71%) ORC6;CCNH;ORC1;...
Ribosome -2.08 0.00e+0 113/158 (71.52%) RPS23;RPL27;RPL21;...
DNA replication -2.13 0.00e+0 34/36 (94.44%) RNASEH2B;POLA1;MCM2;...
RNA transport -2.13 0.00e+0 128/186 (68.82%) PRMT5;CLNS1A;EIF4G2;...
Ribosome biogenesis in eukaryotes -2.14 0.00e+0 52/108 (48.15%) CSNK2A2;RPP38;TCOF1;...
Proteasome -2.19 0.00e+0 44/46 (95.65%) PSMC6;ADRM1;PSMA3;...
Spliceosome -2.57 0.00e+0 101/150 (67.33%) LSM7;SNRPB;PPIE;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 0.12uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.12uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GP2d CVCL_1234 Homo sapiens 0.12uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.12uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 10uM 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 0.12uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.12uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 0.12uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
NCI-H1437 CVCL_1472 Homo sapiens 0.12uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.12uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM - 10uM 24H
HCC1588 CVCL_1263 Homo sapiens 0.12uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.12uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 10uM 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H841 CVCL_1595 Homo sapiens 0.12uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.12uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVK18 CVCL_1629 Homo sapiens 0.12uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 10uM 24H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.12uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.12uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.12uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 10uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.12uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.12uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM - 10uM 24H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 10uM 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 0.12uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM - 10uM 24H