Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPH1AG)

Drug Name
TG100801 Drug Info
Synonyms
867331-82-6; TG 100801; TG100801; UNII-1VZO7A0J9S; TG-100801; 1VZO7A0J9S; 4-Chloro-3-(5-methyl-3-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)amino)benzo[e][1,2,4]triazin-7-yl)phenyl benzoate; 4-Chloro-3-(5-methyl-3-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-amino)benzo[e][1,2,4]triazin-7-yl)phenyl benzoate; C33H30ClN5O3; CHEMBL403989; SCHEMBL12198196; KS-00001CQP; BDBM97971; DTXSID20235791; MolPort-027-835-464; BCP02570; 3641AC; ABP000364; ZINC29136020; AKOS016008711; CS-0785; DB05075; NCGC00378840-01; KB-81090; HY-10186; TG100-801; W-5618
Cross-matching ID
PubChem CID
11973736
ChEBI ID
CHEMBL403989
CAS Number
CAS 867331-82-6
TTD Drug ID
D0GP9Q

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Proteasome 2.36 0.00e+0 44/46 (95.65%) IFNG;PSMD2;PSMB3;...
Ribosome 2.17 0.00e+0 113/158 (71.52%) MRPS16;RPS4Y1;RPL36;...
Spliceosome 2.16 0.00e+0 101/150 (67.33%) EIF4A3;SNRPF;NCBP2;...
Cell cycle 2.08 0.00e+0 110/124 (88.71%) CDC20;SMC1A;MCM6;...
DNA replication 1.93 2.14e-3 34/36 (94.44%) MCM6;RFC4;RPA3;...
Galactose metabolism 1.84 1.78e-2 26/31 (83.87%) MGAM;AKR1B10;PFKL;...
Pentose phosphate pathway 1.84 1.53e-2 25/30 (83.33%) GPI;PFKL;TKTL1;...
Glycolysis / Gluconeogenesis 1.81 1.87e-2 56/67 (83.58%) GPI;PCK1;LDHA;...
RNA degradation 1.80 1.67e-2 53/79 (67.09%) HSPD1;LSM3;PFKL;...
Non-homologous end-joining 1.80 1.50e-2 11/13 (84.62%) XRCC5;DNTT;PRKDC;...
Oxidative phosphorylation 1.76 2.14e-2 93/133 (69.92%) COX6B1;NDUFA1;NDUFB3;...
RNA transport 1.75 2.32e-2 128/186 (68.82%) EIF2S3;EIF4A3;NCBP2;...
Parkinson disease 1.73 2.55e-2 176/249 (70.68%) TUBB;DAXX;UBA1;...
RNA polymerase 1.73 2.37e-2 23/31 (74.19%) POLR2L;POLR2G;POLR2F;...
Amyotrophic lateral sclerosis 1.71 2.57e-2 267/364 (73.35%) TUBB;PFN2;DAXX;...
Huntington disease 1.68 3.48e-2 233/306 (76.14%) TUBB;POLR2L;CREB1;...
Prion disease 1.67 4.22e-2 209/273 (76.56%) TUBB;RAC2;IL1B;...
Pyrimidine metabolism 1.64 4.88e-2 40/56 (71.43%) NT5E;CDA;NME1;...
Cell adhesion molecules -1.95 3.75e-2 118/148 (79.73%) ITGAL;HLA-DPB1;CNTNAP2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H