Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPHCDL)

• Drug Name: GLPG-0634 Drug Info
• Synonyms: Small molecule, JAK1/JAK2 inhibitor (rheumatoid arthritis), Galapagos/GSK
• Cross-matching ID:
  PubChem CID: 49831257
  ChEBI ID: CHEMBL3301607
  CAS Number: CAS 1206161-97-8
  TTD Drug ID: D0SG7B

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Spliceosome	2.37	0.00e+0	101/150 (67.33%)	PRPF4;SRSF7;TCERG1;...
DNA replication	1.90	2.20e-2	34/36 (94.44%)	PCNA;FEN1;RFC5;...
Viral carcinogenesis	1.85	4.40e-2	149/203 (73.4%)	SRC;PIK3R1;PKM;...
Pentose phosphate pathway	1.82	4.03e-2	25/30 (83.33%)	PFKL;PFKP;TKT;...
RNA transport	1.81	3.52e-2	128/186 (68.82%)	EIF4G1;PNN;CYFIP1;...
Citrate cycle (TCA cycle)	1.80	3.42e-2	30/30 (100%)	ACLY;DLST;IDH2;...
Staphylococcus aureus infection	-1.95	4.10e-3	72/95 (75.79%)	KRT33A;C3;FGG;...
Mineral absorption	-2.01	3.07e-3	48/60 (80%)	HEPH;ATP1A2;MT1F;...
Complement and coagulation cascades	-2.37	0.00e+0	76/85 (89.41%)	F2R;C3;FGG;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.04uM - 10uM	6H, 24H, 48H	Hide ▲

Fibrocystic breast disease

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A (Parent)	CVCL_0598	Homo sapiens	1.11uM - 10uM	3H, 6H, 12H, 24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H, 48H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼