General Information of Drug (ID: DMPHRXQ)

Drug Name
spiroxatrine Drug Info
Synonyms spiroxamide
Cross-matching ID
PubChem CID
5268
ChEBI ID
CHEMBL300555
CAS Number
CAS 1054-88-2
TTD Drug ID
D0MU4A

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 1.73 2.30e-1 80/88 (90.91%) THBS1;COL4A3;THBS4;...
Focal adhesion 1.63 3.53e-1 180/201 (89.55%) SRC;THBS1;MYL9;...
Relaxin signaling pathway 1.32 6.14e-1 114/129 (88.37%) SRC;GNG4;COL4A3;...
Cell cycle 1.26 6.15e-1 110/124 (88.71%) PLK1;TGFB1;HDAC1;...
Proteoglycans in cancer 1.25 6.14e-1 172/205 (83.9%) SRC;THBS1;CAV2;...
Amoebiasis 1.25 5.91e-1 99/102 (97.06%) CTSG;COL4A3;TGFB1;...
Oxytocin signaling pathway 1.24 6.06e-1 128/154 (83.12%) SRC;NFATC3;MYL9;...
GABAergic synapse 1.23 6.15e-1 76/89 (85.39%) SRC;GNG4;GNG11;...
Oocyte meiosis 1.23 5.99e-1 90/129 (69.77%) RPS6KA2;PLK1;ITPR3;...
Arrhythmogenic right ventricular cardiomyopathy 1.22 5.94e-1 70/77 (90.91%) ITGA4;TCF7L2;LAMA2;...
Pathogenic Escherichia coli infection 1.21 6.05e-1 152/197 (77.16%) SRC;CLDN10;MYO6;...
Alcoholism 1.21 6.05e-1 86/186 (46.24%) GNG4;GNG11;HDAC1;...
Transcriptional misregulation in cancer 1.21 5.93e-1 158/192 (82.29%) PROM1;WT1;NSD2;...
Phagosome 1.21 5.75e-1 118/152 (77.63%) THBS1;TUBB2A;CALR;...
Tight junction 1.20 5.89e-1 130/169 (76.92%) SRC;CLDN10;MYL9;...
IL-17 signaling pathway 1.18 6.19e-1 84/94 (89.36%) LCN2;MUC5B;CEBPB;...
Sulfur relay system 1.18 6.02e-1 5/8 (62.5%) MPST;TST;NFS1;...
Hypertrophic cardiomyopathy 1.17 6.04e-1 81/90 (90%) TGFB1;ITGA4;TPM1;...
Arginine and proline metabolism 1.15 6.21e-1 39/50 (78%) GATM;SRM;ALDH18A1;...
PI3K-Akt signaling pathway 1.14 6.22e-1 317/354 (89.55%) THBS1;GNG4;COL4A3;...
Human T-cell leukemia virus 1 infection 1.13 6.18e-1 197/219 (89.95%) NFATC3;CALR;TGFB1;...
Thyroid hormone signaling pathway 1.13 6.08e-1 112/121 (92.56%) SRC;HDAC1;FXYD2;...
Base excision repair 1.12 6.13e-1 29/33 (87.88%) NEIL3;LIG1;POLE2;...
Purine metabolism 1.12 6.06e-1 102/129 (79.07%) ENPP1;PRPS2;GUCY1B1;...
Other types of O-glycan biosynthesis 1.11 6.17e-1 29/47 (61.7%) ST6GAL1;GALNT10;GALNT6;...
Hedgehog signaling pathway 1.11 6.23e-1 43/56 (76.79%) GAS1;IQCE;CCND1;...
Sulfur metabolism 1.11 6.11e-1 9/10 (90%) SQOR;PAPSS2;MPST;...
Human cytomegalovirus infection 1.11 6.08e-1 201/225 (89.33%) SRC;NFATC3;GNG4;...
Melanoma 1.10 6.20e-1 68/72 (94.44%) PDGFRA;PDGFRB;EGF;...
cGMP-PKG signaling pathway 1.10 6.11e-1 145/167 (86.83%) NFATC3;MYL9;ITPR3;...
Staphylococcus aureus infection -1.33 4.92e-1 72/95 (75.79%) HLA-DRA;FPR1;CFI;...
HIF-1 signaling pathway -1.34 4.65e-1 105/109 (96.33%) MAP2K1;ENO3;ELOC;...
Intestinal immune network for IgA production -1.34 4.74e-1 38/48 (79.17%) HLA-DQB1;TNFRSF17;HLA-DOA;...
Antigen processing and presentation -1.35 4.68e-1 60/78 (76.92%) HLA-DQB1;KLRD1;RFXANK;...
Taurine and hypotaurine metabolism -1.35 4.78e-1 8/11 (72.73%) GAD1;GAD2;BAAT;...
Synaptic vesicle cycle -1.35 4.86e-1 63/78 (80.77%) CLTB;ATP6V0E1;SLC6A12;...
Metabolism of xenobiotics by cytochrome P450 -1.36 4.87e-1 49/77 (63.64%) ADH7;CYP2C9;GSTK1;...
Inflammatory bowel disease -1.36 5.07e-1 58/65 (89.23%) IL4R;HLA-DRA;IL18;...
Inositol phosphate metabolism -1.37 4.80e-1 66/73 (90.41%) INPP5B;PIK3CB;PIK3CD;...
Protein processing in endoplasmic reticulum -1.41 3.64e-1 127/171 (74.27%) MAN1B1;DERL1;FBXO2;...
Melanogenesis -1.42 3.53e-1 74/101 (73.27%) TCF7L1;CREBBP;CALML3;...
Cytokine-cytokine receptor interaction -1.43 3.40e-1 246/295 (83.39%) TNFRSF17;IL7;TNFRSF1A;...
Other glycan degradation -1.44 3.19e-1 13/18 (72.22%) HEXA;HEXB;NEU1;...
Folate biosynthesis -1.46 3.11e-1 23/26 (88.46%) MOCS1;ALPG;MOCS2;...
Epithelial cell signaling in Helicobacter pylori infect... -1.47 2.85e-1 62/70 (88.57%) ATP6V1H;ATP6V1B2;JUN;...
Vibrio cholerae infection -1.49 2.77e-1 44/50 (88%) ATP6V1H;ATP6V1B2;SEC61B;...
Hematopoietic cell lineage -1.51 2.26e-1 90/99 (90.91%) CD36;HLA-DQB1;IL7;...
Toll-like receptor signaling pathway -1.56 1.68e-1 94/104 (90.38%) LBP;CCL4;MAPK9;...
Renin-angiotensin system -1.56 1.82e-1 20/23 (86.96%) CPA3;KLK2;PRCP;...
Rheumatoid arthritis -1.56 1.93e-1 78/93 (83.87%) HLA-DQB1;TEK;HLA-DOA;...
Allograft rejection -1.58 1.75e-1 32/38 (84.21%) HLA-DQB1;HLA-DOA;HLA-DOB;...
Autoimmune thyroid disease -1.62 1.40e-1 46/53 (86.79%) CD86;TSHR;HLA-DRA;...
Viral protein interaction with cytokine and cytokine re... -1.65 1.27e-1 84/100 (84%) CCR3;PPBP;IL10RA;...
Renin secretion -1.66 1.33e-1 61/69 (88.41%) EDN3;PTGER4;PPP3CA;...
African trypanosomiasis -1.68 1.30e-1 32/37 (86.49%) IL18;IL1B;IL6;...
Mineral absorption -1.69 1.35e-1 48/60 (80%) SLC31A1;TF;SLC30A1;...
Oxidative phosphorylation -1.72 1.28e-1 93/133 (69.92%) NDUFB2;NDUFA9;ATP5PF;...
Collecting duct acid secretion -1.72 1.71e-1 22/27 (81.48%) ATP6V0E1;ATP4A;TCIRG1;...
Primary immunodeficiency -1.76 1.57e-1 33/38 (86.84%) LCK;RAG1;RFXANK;...
Graft-versus-host disease -1.81 1.52e-1 32/42 (76.19%) HLA-DQB1;KLRD1;HLA-DOA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 8uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H