Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPHZI5)

Drug Name
NBQX Drug Info
Synonyms
nbqx; 118876-58-7; FG 9202; 2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline; 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline; 6-Nitro-7-sulfamoylbenzo(f)quinoxaline-2,3-dione; CHEMBL222519; CHEBI:31073; SBB066176; 6-nitro-2,3-dioxo-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide; 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxobenzo(f)quinoxaline-8-sulfonamide; 6-Nitro-7-sulphamoylbenzo[f]quinoxaline-2,3-dione; 6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-Dione; 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline
Cross-matching ID
PubChem CID
3272524
ChEBI ID
CHEMBL222519
CAS Number
CAS 118876-58-7
TTD Drug ID
D02VKC

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mismatch repair 1.88 2.52e-2 22/23 (95.65%) PCNA;RFC5;RFC2;...
DNA replication 1.79 4.72e-2 34/36 (94.44%) PCNA;RFC5;RFC2;...
Ferroptosis -1.64 4.89e-2 36/41 (87.8%) ACSL4;TFRC;ACSL1;...
Viral protein interaction with cytokine and cytokine re... -1.66 4.14e-2 84/100 (84%) CXCR4;IL6ST;LTBR;...
Terpenoid backbone biosynthesis -1.66 4.21e-2 18/22 (81.82%) HMGCR;ICMT;FNTA;...
Human cytomegalovirus infection -1.67 4.21e-2 201/225 (89.33%) PIK3R2;E2F3;IL1B;...
Pancreatic secretion -1.67 4.37e-2 87/102 (85.29%) PLA2G10;ATP1A1;PRSS1;...
Steroid biosynthesis -1.68 4.38e-2 19/20 (95%) CYP24A1;FDFT1;NSDHL;...
Biosynthesis of unsaturated fatty acids -1.68 4.57e-2 21/27 (77.78%) ELOVL1;ELOVL2;HACD2;...
Amoebiasis -1.71 3.95e-2 99/102 (97.06%) PIK3R2;IL1B;IL1R1;...
Longevity regulating pathway -1.72 3.74e-2 90/151 (59.6%) ULK1;CREB3L1;PIK3R2;...
Cortisol synthesis and secretion -1.74 3.71e-2 58/65 (89.23%) HSD3B2;MC2R;CREB3;...
Salivary secretion -1.75 3.68e-2 76/93 (81.72%) ATP2B4;ATP1B4;MUC7;...
Synaptic vesicle cycle -1.77 3.26e-2 63/78 (80.77%) SLC18A2;ATP6V1A;ATP6V1F;...
Endocrine and other factor-regulated calcium reabsorpti... -1.81 2.48e-2 49/53 (92.45%) ATP2B4;ATP1B4;SLC8A1;...
Rheumatoid arthritis -1.85 1.38e-2 78/93 (83.87%) PTH;HLA-DQA1;CSF2;...
Aldosterone synthesis and secretion -1.90 8.62e-3 85/98 (86.73%) HSD3B2;MC2R;CREB3;...
Sphingolipid metabolism -1.91 7.88e-3 32/49 (65.31%) GLB1;KDSR;GAL3ST1;...
Legionellosis -1.92 9.19e-3 51/57 (89.47%) IL1B;CASP3;BCL2L13;...
Collecting duct acid secretion -1.93 8.27e-3 22/27 (81.48%) ATP6V1A;ATP6V1F;ATP6V0A2;...
alpha-Linolenic acid metabolism -1.96 3.45e-3 17/25 (68%) PLA2G1B;PLA2G12A;PLA2G2A;...
Vibrio cholerae infection -2.01 0.00e+0 44/50 (88%) ATP6V1A;ARF1;ATP6V1F;...
Protein processing in endoplasmic reticulum -2.14 0.00e+0 127/171 (74.27%) DNAJC1;SEC63;YOD1;...
Lysosome -2.31 0.00e+0 115/128 (89.84%) ATP6V0A2;CTSO;ATP6V0A4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H