General Information of Drug (ID: DMPI6Z0)

Drug Name
Zopiclone Drug Info
Synonyms
Amoban; Amovane; Imovance; Imovane; Limovan; Optidorm; Rhovane; Siaten; Sopivan; Ximovan; Zileze; Zimoclone; Zimovane; Zopicalm; Zopicalma; Zopiclodura; Zopiclona; Zopiclonum; Zopitan; Zorclone; AbZ brand of zopiclone; Aliud brand of zopiclone; Alpharma brand of zopiclone; Aventis Pharma brand of zopiclone; Aventis brand of zopiclone; Azupharma brand of zopiclone; Betapharm brand of zopiclone; Ciclum brand of zopiclone; Clonmel brand of zopiclone; Dolorgeit brand of zopiclone; Gerard brand of zopiclone; Hexal brand of zopiclone; Hormosan brand of zopiclone; Italfarmaco brand of zopiclone; Merck dura brand of zopiclone; Neuraxpharm brand of zopiclone; Norton brand of zopiclone; Opus brand of zopiclone; Pinewood brand of zopiclone; Ratiopharm brand of zopiclone; Rhodiapharm brand of zopiclone; Stadapharm brand of zopiclone; TAD brand of zopiclone; Temmler brand of zopiclone; Teva brand of zopiclone; Zopiclon AL; Zopiclon AZU; Zopiclon AbZ; Zopiclon Stada; Zopiclon TAD; Zopiclon beta; Zopiclon von ct; RP 27 267; RP 27267; Z 4900; Z4900_SIGMA; Amoban (TN); Ct-Arzneimittel brand of zopiclone; Imovane (TN); Novo-zopiclone; Nu-Pharm brand of zopiclone; Nu-Zopiclone; RP-27267; Ran-zopiclone; Ratio-Zopiclone; Rhone-Poulenc Rorer brand of zopiclone; Zimovane (TN); Zopi-Puren; Zopiclon-TEVA; Zopiclon-neuraxpharm; Zopiclon-ratiopharm; Zopiclona [INN-Spanish]; Zopiclone (TN); Zopiclonum [INN-Latin]; Zopinox (TN); Zopiclone (JAN/INN); Zopiclone [BAN:INN:JAN]; Zopiclone, Imovane, Zimovane, Lunesta; [6-(5-chloropyridin-2-yl)-5-oxo-7H-pyrrolo[3,4-b]pyrazin-7-yl] 4-methylpiperazine-1-carboxylate; 1-Piperazinecarboxylic acid, 4-methyl-, 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl ester; 1-Piperazinecarboxylic acid, 4-methyl-, 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl ester; 4-Methyl-1-piperazinecarboxylic acid 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl ester; 4-Methyl-1-piperazinecarboxylic acid ester with 6-(5-chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo(3,4-b)pyrazin-5-one; 6-(5-Chloro-2-pyridinyl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methyl-1-piperazinecarboxylate; 6-(5-chloro-2-pyridyl)-6,7-dihydro-7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl 4-methyl-1-piperazinecarboxylate; 6-(5-chloropyrid-2-yl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine; 6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate
Therapeutic ClassHypnotics and Sedatives
Cross-matching ID
PubChem CID
5735
ChEBI ID
CHEMBL135400
CAS Number
CAS 43200-80-2
TTD Drug ID
D0ZB7K
INTEDE Drug ID
DR1738

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Cell cycle 2.34 0.00e+0 110/124 (88.71%) CCND2;CDK2;TGFB3;...
DNA replication 2.22 0.00e+0 34/36 (94.44%) FEN1;MCM4;LIG1;...
Morphine addiction 1.99 3.30e-3 80/91 (87.91%) GNAS;GNG11;GNG12;...
Oocyte meiosis 1.82 1.98e-2 90/129 (69.77%) CDK2;CCNE2;ESPL1;...
Fanconi anemia pathway 1.79 1.98e-2 36/54 (66.67%) USP1;FANCG;FANCI;...
Mismatch repair 1.78 1.98e-2 22/23 (95.65%) LIG1;RFC4;RPA1;...
p53 signaling pathway 1.76 1.84e-2 63/73 (86.3%) CCND2;CDK2;CCNE2;...
RNA transport 1.68 4.83e-2 128/186 (68.82%) NUP85;NUP107;CYFIP2;...
Fatty acid biosynthesis -1.60 4.21e-2 16/18 (88.89%) MECR;ACSL5;ACACA;...
Pentose phosphate pathway -1.65 2.68e-2 25/30 (83.33%) PGD;ALDOC;PGLS;...
Epithelial cell signaling in Helicobacter pylori infect... -1.65 2.77e-2 62/70 (88.57%) ATP6V0D1;MAPK11;TJP1;...
Retinol metabolism -1.66 2.73e-2 41/68 (60.29%) RDH16;ALDH1A3;UGT2B4;...
Tyrosine metabolism -1.66 2.83e-2 30/36 (83.33%) MAOB;TH;DBH;...
Mineral absorption -1.67 2.62e-2 48/60 (80%) MT1H;ATP1B2;ATP2B1;...
Propanoate metabolism -1.67 2.56e-2 30/34 (88.24%) ECHS1;PCCA;ACADS;...
Mitophagy -1.68 2.54e-2 56/68 (82.35%) BCL2L13;MAPK10;CITED2;...
Butanoate metabolism -1.75 1.24e-2 23/28 (82.14%) ECHS1;HMGCS2;ACADS;...
Legionellosis -1.75 1.30e-2 51/57 (89.47%) CD14;HSPD1;BCL2L13;...
NF-kappa B signaling pathway -1.76 1.21e-2 90/104 (86.54%) TRAF1;CSNK2A2;NFKB1;...
Glyoxylate and dicarboxylate metabolism -1.77 1.17e-2 23/30 (76.67%) AGXT;HAO1;PCCA;...
Lysine degradation -1.77 1.23e-2 51/63 (80.95%) PIPOX;ACAT1;DHTKD1;...
Sulfur metabolism -1.78 1.25e-2 9/10 (90%) PAPSS2;MPST;ETHE1;...
Ascorbate and aldarate metabolism -1.80 8.83e-3 15/30 (50%) AKR1A1;ALDH3A2;ALDH2;...
Terpenoid backbone biosynthesis -1.81 9.42e-3 18/22 (81.82%) PDSS2;MVK;DHDDS;...
Pyruvate metabolism -1.82 8.65e-3 41/47 (87.23%) ACAT1;ADH6;GRHPR;...
Folate biosynthesis -1.84 6.21e-3 23/26 (88.46%) ALPL;ALPG;SPR;...
Tryptophan metabolism -1.85 6.73e-3 35/42 (83.33%) KMO;ECHS1;HAAO;...
Metabolism of xenobiotics by cytochrome P450 -1.87 3.67e-3 49/77 (63.64%) CYP2A13;UGT2B4;CYP2C9;...
Valine, leucine and isoleucine degradation -1.87 4.04e-3 42/48 (87.5%) ECHS1;PCCA;HMGCS2;...
Primary bile acid biosynthesis -1.87 4.48e-3 15/17 (88.24%) CYP7A1;BAAT;SCP2;...
Nicotinate and nicotinamide metabolism -1.89 3.78e-3 25/35 (71.43%) NMRK2;NT5M;BST1;...
Steroid hormone biosynthesis -1.91 4.32e-3 43/61 (70.49%) SRD5A3;CYP11B2;STS;...
Protein processing in endoplasmic reticulum -1.94 3.36e-3 127/171 (74.27%) SSR2;SEC61A2;HSPH1;...
Ferroptosis -1.96 4.04e-3 36/41 (87.8%) SLC3A2;ACSL5;SAT1;...
Biosynthesis of unsaturated fatty acids -1.97 5.04e-3 21/27 (77.78%) FADS1;ELOVL2;ELOVL5;...
Fatty acid degradation -1.97 6.73e-3 40/43 (93.02%) ACADS;ADH1A;ACADVL;...
Steroid biosynthesis -2.16 0.00e+0 19/20 (95%) CYP24A1;SQLE;TM7SF2;...
Peroxisome -2.17 0.00e+0 72/82 (87.8%) PXMP4;SLC27A2;PEX7;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H